Presented by

Johns Hopkins University School of Medicine

Activity Details

Statement of Educational Need
Lung cancer is the leading cause of cancer-related mortality in the United States, accounting for more deaths than breast, prostate, and colon cancers combined. About 65% of the patients diagnosed with lung carcinomas are diagnosed at an advanced stage and most of these patients relapse resulting in poor prognosis. Non-small cell lung cancer (NSCLC) management is becoming increasingly complex and data continues to emerge, hence a comprehensive knowledge of multiple issues such as the role molecular profiling and histology subtyping on the choice of first-line and maintenance therapies will assist clinicians in their efforts to provide optimal care. To aid this process, this educational initiative will be presented as an enduring Podcast activity. Specific topics that will be discussed include the current understanding in combining targeted therapies with first-line therapies. The influence of histology and molecular profiling in choosing appropriate Food and Drug Administration (FDA)-approved first-line therapies for advanced stage or metastatic NSCLC involving third generation antifolate and cytotoxics and the role of maintenance therapy in managing patients with NSCLC will also be discussed.

Learning Objectives
After completing the educational activity, learners will demonstrate the ability to:

• Assess the safety and efficacy of third generation antifolate/cytotoxic drugs used in first-line treatment of advanced stage or metastatic NSCLC
• Evaluate the role of maintenance therapy in managing patients with NSCLC based on current clinical evidence
• Discuss the influence of histological and molecular subtyping of patients with NSCLC on the choice of therapy
• Provide appropriate care and counsel for patients and their families

The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.

Target Audience
This activity is designed for medical oncologists, registered nurses, and other healthcare professionals who are interested in treating patients with non-small cell lung cancer with pharmacological agents. There are no prerequisites.

Requirements for Successful Completion
In order to receive a certificate of participation, participants must listen to the podcast and complete a participant evaluation and a post-test. A grade of at least 70% is needed on the post-test to receive a CME certificate. Physicians must attest to the amount of time they have spent on the activity.

Disclosure of Conflicts of Interest
As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of the Johns Hopkins University School of Medicine Office of Continuing Medical Education (OCME) to require signed disclosure of the existence of financial relationships with industry from any individual in a position to control the content of a CME activity sponsored by OCME. Members of the Planning Committee are required to disclose all relationships regardless of their relevance to the content of the activity. Faculty are required to disclose only those relationships that are relevant to their specific presentation. The following relationships have been reported for this activity:

Planner's Disclosures

No other planners have indicated that they have any financial interests with a commercial entity.

The following PIM planners and managers, Jan Hixon, RN, BSN, MA, Trace Hutchison, PharmD, Julia Kimball, RN, BSN, Samantha Mattiucci, PharmD, Jan Schultz, RN, MSN, CCMEP, Patricia Staples, MSN, NP-C, CCRN hereby state that they or their spouse/life partner do not have any financial relationships or relationships to products or devices with any commercial interest related to the content of this activity of any amount during the past 12 months.

Note: Grants to investigators at The Johns Hopkins University are negotiated and administered by the institution which receives the grants, typically through the Office of Research Administration. Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor, but may receive salary or other support from the institution to support their effort on the project(s).

Physician
Accreditation Statement
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of the Johns Hopkins University School of Medicine and the Postgraduate Institute for Medicine. The Johns Hopkins University School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation
The Johns Hopkins University School of Medicine designates this enduring material for a maximum of .75 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Academy of Nurse Practitioners (AANP) accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.

American Academy of Physician Assistants (AAPA) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Physician assistants may receive a maximum of .75 hours of Category 1 credit for completing this program.

Nurse
Accreditation Statement
The Postgraduate Institute for Medicine is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.

Credit Designation
This educational activity for 1.0 contact hours is provided by Postgraduate Institute for Medicine.

Statement of Commercial Support
Supported by an educational grant from Lilly USA, LLC.

Disclaimer Statement
The opinions and recommendations expressed by faculty and other experts whose input is included in this program are their own. This enduring material is produced for educational purposes only. Use of Johns Hopkins University School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.

Disclosure of Unlabeled Use
The following speakers have disclosed that their presentation will reference unlabeled/unapproved uses of drugs or products:

Hardware / Software Requirements

• Flash Player 6.0.79 or later (http://www.adobe.com/go/getflash) (Flash Player 7 or later recommended), and one of the following browsers:
• Windows: Internet Explorer 6, Internet Explorer 7, Firefox 1.x and later, Safari 3, Google Chrome, Opera 9.5
• Macintosh: Firefox 1.x and later, Safari 3
• Linux: Firefox 1.x

Instructions for Receiving Credit
If you wish to receive acknowledgement for completing this activity, please complete the post-test and evaluation following the activity. Successfully completing the post-test with a score of 70% or better and the activity evaluation, your certificate will be made available immediately.

Privacy Policy
The Office of Continuing Medical Education (CME) at the Johns Hopkins University School of Medicine is committed to protecting the privacy of its members and customers. Johns Hopkins University SOM CME maintains its Internet site as an information resource and service for physicians, other health professionals and the public. Continuing Medical Education at the Johns Hopkins University School of Medicine will keep your personal and credit information confidential when you participate in a CME Internet based program. Your information will never be given to anyone outside of the Johns Hopkins University School of Medicine’s CME program. CME collects only the information necessary to provide you with the services that you request.

CONFIDENTIALITY DISCLAIMER FOR CME CONFERENCE ATTENDEES

I certify that I am attending a Johns Hopkins University School of Medicine CME activity for accredited training and/or educational purposes.

I understand that while I am attending in this capacity, I may be exposed to "protected health information," as that term is defined and used in Hopkins policies and in the federal HIPAA privacy regulations (the "Privacy Regulations"). Protected health information is information about a person’s health or treatment that identifies the person.

I pledge and agree to use and disclose any of this protected health information only for the training and/or educational purposes of my visit and to keep the information confidential.

I understand that I may direct to the Johns Hopkins Privacy Officer any questions I have about my obligations under this Confidentiality Pledge or under any of the Hopkins policies and procedures and applicable laws and regulations related to confidentiality. The contact information is: Johns Hopkins Privacy Officer, telephone: 410-735-6509, e-mail: HIPAA@jhmi.edu.

“The Office of Continuing Medical Education at the Johns Hopkins University School of Medicine, as provider of this activity, has relayed information with the CME attendees/participants and certifies that the visitor is attending for training, education and/or observation purposes only.”

For CME Questions, please contact the CME Office at (410) 955-2959 or e-mail cmenet@jhmi.edu.
For CME Certificates, please call (410) 502-9634.

Johns Hopkins University School of Medicine
Office of Continuing Medical Education
Turner 20/720 Rutland Avenue
Baltimore, Maryland 21205-2195

Reviewed & Approved by:
General Counsel, Johns Hopkins Medicine (4/1/03)
Updated 4/09

Copyright © 2011 Johns Hopkins University School of Medicine