Activity Details

Free CME
0.75 AMA PRA Category 1 Credit(s)
Released: September 30, 2019
Expires: September 29, 2020
45 minutes to complete

Accredited By

Advancing Knowledge in Healthcare (AKH, Inc.)

Target Audience

This educational activity is designed for rheumatology healthcare professionals who manage patients with rheumatoid arthritis (RA).

Learning Objectives

Upon completion of this educational activity, participants should be able to:

  • Describe involvement of the IL-6 signaling pathway in the pathophysiology, extra-articular symptomology, and associated comorbidities of rheumatoid arthritis (RA), and the role of cytokine-targeted therapy in the treatment of RA 
  • Incorporate validated and guideline-recommended RA disease activity monitoring to guide appropriate management of patients 
  • Use a treat-to-target approach for managing RA that personalizes therapy by cycling or switching treatment options in nonresponsive patients, and takes into account data for new and emerging biologic and targeted synthetic DMARDs 
  • Incorporate patient preferences, shared decision making, and patient education into the management plan for patients with RA 

Activity Description

Is a JAK inhibitor an oral IL-6 inhibitor? Is there a typical “TNFi-patient” versus an “IL-6i patient?” How do IL-6 inhibitors affect mood if they don’t cross the blood-brain barrier? We’ve sourced some of the most pressing questions about rheumatoid arthritis (RA) from leaders around the world, and then brought them together to discuss them. We’ve also asked a patient with RA about her experience with the disease and its treatment. In this activity, we put their expert opinion against a patient’s true story. Will they match up?

Statement of Educational Need

Suboptimal management of patients with rheumatoid arthritis (RA) results in disability, inability to work, and substantial direct and indirect cost burden. Outcomes data from previous RA programs and from the literature indicate that despite the fact that effective use of disease-modifying antirheumatic drugs (DMARDs) greatly reduces the potential for joint destruction, systemic immune effects, and disability, rheumatology providers are not effectively utilizing DMARDs, switching drugs when appropriate, utilizing appropriate monitoring tools, using effective SDM strategies to optimize care, nor effectively selecting newer agents when making treatment decisions.


>Paul Emery, MA, MD, FRCP, FMedSci, MARC (Chair)
Paul Emery, MA, MD, FRCP, FMedSci, MARC (Chair)
Arthritis Research UK Professor, Rheumatology  
Director, NIHR Leeds Biomedical Research Centre
Leeds Teaching Hospitals NHS Trust
Leeds Institute of Rheumatic and Musculoskeletal Medicine
University of Leeds
Leeds, UK

Leonard H. Calabrese, DO
Leonard H. Calabrese, DO
Professor of Medicine, Cleveland Clinic Lerner College of Medicine  
Case Western Reserve University
Vice Chairman, Department of Rheumatic and Immunological Diseases  
R. J. Fasenmyer Chair of Clinical Immunology  
Cleveland Clinic 
Cleveland, OH

Ernest Choy, MD, FRCP
Ernest Choy, MD, FRCP
Professor, Head of Rheumatology and Translational Research  
Division of Infection and Immunity  
Director, Arthritis Research UK CREATE Centre and Welsh Arthritis Research Network (WARN)  
Cardiff University School of Medicine  
Cardiff, UK

Conflict of Interest Policy/ Disclosure Statement

It is the policy of AKH Inc., Advancing Knowledge in Healthcare and RMEI Medical Education, LLC, to ensure independence, balance, objectivity, scientific rigor, and integrity in all of their continuing education activities. The faculty must disclose to the participants any significant relationships with commercial interests whose products or devices may be mentioned in the activity or with the commercial supporter of this continuing education activity. Identified conflicts of interest are resolved by RMEI and AKH prior to accreditation of the activity and may include any of, or a combination of, the following: attestation to non-commercial content; notification of independent and certified CME/CE expectations; referral to National Faculty Initiative training; restriction of topic area or content; restriction to discussion of science only; amendment of content to eliminate discussion of device or technique; use of other faculty for discussion of recommendations; independent review against criteria ensuring evidence supports the recommendation; moderator review; and peer review. AKH planners and reviewers have no relevant financial relationships to disclose.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:

  • Leonard H. Calabrese, DO, has affiliations with AbbVie, Amgen, BMS, Crescendo, Genentech, Gilead, GSK, Horizon, Janssen, Lily, Pfizer, Sanofi-Genzyme, UCB (Consultant); AbbVie, BMS, Genentech, Horizon, Janssen, Lily, Sanofi (Speakers Bureau).
  • Ernest Choy, MD, FRCP, has affiliations with Bio-Cancer, Biogen, Novartis, Novimmune, Pfizer, Roche, Sanofi, UCB (Contracted Research); AbbVie, Amgen, Biogen, Chugai Pharma, Eli Lilly, Janssen, Novartis, Pfizer, Regeneron, Roche, R-Pharm, Sanofi (Consultant); Amgen, BMS, Boehringer Ingelheim, Chugai Pharma, Eli Lilly, Hospira, MSD, Novartis, Pfizer, Regeneron, Roche, Sanofi-Aventis, UCB (Speakers Bureau).
  • Paul Emery, MA, MD, FRCP, FMedSci, MARC (Chair), has affiliations with AbbVie, Amgen, BMS, Gilead, Lilly, MSD, Novartis, Pfizer, Samsung, Sanofi (Consultant).

The planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:

RMEI Medical Education, LLC

  • Lobna Eldasher, PharmD, has no affiliations with commercial interests to disclose.
  • Sharon Powell has no affiliations with commercial interests to disclose.

 AKH Staff and Planners

  • Dorothy Caputo, MA, BSN, RN, Director of Accreditation, Planner, has no affiliations with commercial interests to disclose.
  • Patricia Brignoni, AKH, Director of Operations, has disclosed no relevant financial relationships.

Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of AKH Inc., Advancing Knowledge in Healthcare and RMEI Medical Education, LLC. AKH Inc., Advancing Knowledge in Healthcare is accredited by the ACCME to provide continuing medical education for physicians.

AKH Inc., Advancing Knowledge in Healthcare designates this enduring activity for a maximum of 0.75 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Physician Assistants
The National Commission on Certification of Physician Assistants (NCCPA) accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME.

Instructions for Receiving Credit

By reviewing the course content and successfully completing the post-test and evaluation, physicians and PAs are entitled to receive up to 0.75 AMA PRA Category 1 Credit(s)™. A statement of credit will be available to print immediately. Users must:

  • Read the learning objectives and faculty disclosures.
  • Participate in the activity.
  • Complete the activity post-test and evaluation.

Physicians and PAs who successfully complete the post-test and evaluation will receive CME/CE credit. You must score 75% or higher on the post-test to receive credit for this activity. All other participants who successfully complete the post-test and evaluation will receive a certificate of participation. If you have questions about this CE activity, please contact AKH Inc. at

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*The expense for this gift card is solely funded by RMEI Medical Education, LLC.
No supporter funding was used for the expense of this gift card.

Rules and Regulations 
This sweepstakes is managed by RMEI Medical Education, LLC (RMEI), a full-service medical education company. The winner will be selected via automated random drawing on a monthly basis from among all eligible entries and notified through the contact information provided. In accordance with our privacy policy, we do not share your information with any third parties. By entering the sweepstakes, you grant RMEI permission to use your e-mail address to reach you for notification and prize fulfillment. Only individuals who complete the evaluation forms and provide contact information will be eligible to win. Open to those who have a US postal address and who are 18 years or older. Only one prize per person and per household will be awarded. The prize will be a $100 Amazon gift card.

Statement of Commercial Support

This educational activity is supported by an independent medical educational grant from Sanofi Genzyme and Regeneron Pharmaceuticals.

Disclaimer Statement

This course is designed solely to provide the healthcare professional with information to assist in his/her practice and professional development and is not to be considered a diagnostic tool to replace professional advice or treatment. The course serves as a general guide to the healthcare professional, and therefore, cannot be considered as giving legal, nursing, medical, or other professional advice in specific cases. AKH Inc. specifically disclaims responsibility for any adverse consequences resulting directly or indirectly from information in the course, for undetected error, or through participant's misunderstanding of the content.

Disclosure of Unlabeled Use and Investigational Product

This educational activity may include discussion of uses of agents that are investigational and/or unapproved by the FDA. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Contact Information for Questions about the Activity

Please contact Nicole Neely at for questions regarding this activity.

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