Activity Chair

Leonard H. Calabrese, DO
Professor of Medicine, Cleveland Clinic Lerner
College of Medicine of Case Western Reserve University
RJ Fasenmyer Chair of Clinical Immunology
Theodore F. Classen, DO Chair of Osteopathic Research and Education
Vice Chairman, Department of Rheumatic and Immunologic Diseases
Cleveland, OH


Gerald B. Appel, MD
Co-Director, Clinical Nephrology
New York-Presbyterian Hospital/Columbia University Medical Center
Professor, Clinical Medicine
Director, Glomerular Kidney Disease Center
Columbia University College of Physicians and Surgeons
New York, NY

Curry L. Koening, MD, MS
Assistant Professor
Division of Rheumatology
Department of Internal Medicine
University of Utah Health Sciences Center
Salt Lake City, UT


Chester Oddis, MD

Ronald A. Codario, MD, FACP, FNLA, RPVI, CHCP

Provider Statement

This continuing medical education activity is provided by

Activity Details

Credit Type: AMA PRA Category 1 Credit
Credit Amount: 0.75 AMA PRA Category 1 Credit(s)
Release Date: April 29, 2016
Expiration Date: April 29, 2017
Estimated Time to Complete Activity: 45 minutes
Registration Required: No
Fee for Activity: There is no fee for participating in this activity.

Support Statement

This activity is supported by an educational grant from Genentech, Inc.

Target Audience

The intended audience for the activity is rheumatologists, nephrologists, and other health care professionals involved in the treatment of patients with ANCA-associated vasculitis (AAV).

Learning Objectives

Upon successful completion of this educational activity, participants should be better able to:

  • Apply a rational approach for the differential diagnosis of ANCA-associated vasculitis.
  • Detail the appropriate diagnostic tests to order and the interpretation of these tests to establish the correct diagnosis in patients suspected of having ANCA-associated vasculitis.
  • Utilize pharmacotherapies for the induction and maintenance phases of ANCA-associated vasculitis based upon up-to-date clinical evidence on their safety and efficacy profiles.
  • Apply knowledge of clinical data so as to ensure safety and efficacy when prescribing treatments for patients with ANCA-associated vasculitis and comorbidities.
  • Explain the rationale for a multidisciplinary team approach in the diagnosis and management of ANCA-related vasculitis.


Vindico Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation

Vindico Medical Education designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This enduring material is approved for 1 year from the date of original release, April 29, 2016 through April 29, 2017.

How To Participate in this Activity and Obtain CME Credit

To participate in this CME activity, you must answer the pretest questions, complete the clinical case, complete the CME posttest, and complete the evaluation. Provide only one (1) correct answer for each question. A satisfactory score is defined as answering 4 out of 5 of the posttest questions correctly. Upon receipt of the completed materials, if a satisfactory score on the posttest is achieved, Vindico Medical Education will issue an AMA PRA Category 1 Credit(s)™ Certificate.


In accordance with the Accreditation Council for Continuing Medical Education’s Standards for Commercial Support, all CME providers are required to disclose to the activity audience the relevant financial relationships of the planners, teachers, and authors involved in the development of CME content. An individual has a relevant financial relationship if he or she has a financial relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the CME activity content over which the individual has control.

The authors disclose that they do have significant financial interests in any products or class of products discussed directly or indirectly in this activity, including research support.

Planning Committee and Faculty members report the following relationship(s):
Gerald B. Appel, MD
Royalty: UpToDate
Consulting Fee: EMD Serono, Genentech, Ionis Pharmaceuticals (formerly Isis Pharmaceuticals) Mallinckrodt, Merck, Pfizer, Takeda
Speakers Bureau: Genentech, Takeda

Leonard H. Calabrese, DO
Consulting Fee:  GlaxoSmithKline, Janssen, Pfizer, Sanofi
Speakers Bureau: AbbVie, Bristol-Myers Squibb, Crescendo, Genentech, Janssen

Curry L. Koening, MD, MS
Site Principle Investigator: Bristol-Myers Squibb, Genentech
Sub-Investigator: GlaxoSmithKline
Vasculitis Clinical Research Consortium Steering Committee: National Institutes of Health

Reviewers report the following relationship(s):
Chester Oddis, MD
Consulting Fee: aTyr Pharma, Momenta Pharmaceuticals, Novartis, Regeneron
Contracted Research: Genentech, Mallinckrodt Pharmaceuticals
Advisory Board: Novartis

Ronald A. Codario, MD, FACP, FNLA, RPVI, CHCP

No relevant financial relationships to disclose.

Vindico Medical Education staff report the following relationship(s):
No relevant financial relationships to disclose.

Signed disclosures are on file at Vindico Medical Education, Office of Medical Affairs and Compliance.

Unlabeled and Investigational Usage

The audience is advised that this continuing medical education activity may contain references to unlabeled uses of FDA-approved products or to products not approved by the FDA for use in the United States. The faculty members have been made aware of their obligation to disclose such usage. All activity participants will be informed if any speakers/authors intend to discuss either non-FDA approved or investigational use of products/devices.

Copyright Statement

Created and published by Vindico Medical Education, 6900 Grove Road, Building 100, Thorofare, NJ 08086-9447. Telephone: 856-994-9400; Fax: 856-384-6680. Printed in the USA. Copyright © 2016 Vindico Medical Education. All rights reserved. No part of this publication may be reproduced without written permission from the publisher. The material presented at or in any of Vindico Medical Education continuing medical education activities does not necessarily reflect the views and opinions of Vindico Medical Education. Neither Vindico Medical Education nor the faculty endorse or recommend any techniques, commercial products, or manufacturers. The faculty/authors may discuss the use of materials and/or products that have not yet been approved by the US Food and Drug Administration. All readers and continuing education participants should verify all information before treating patients or utilizing any product.

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