Activity Chair

Prof. Hans-Peter Hartung, MD, FRCP, FAAN, FANA
Professor and Chairman
Department of Neurology
Heinrich-Heine-Universität Düsseldorf
Düsseldorf, Germany

Planning Committee and Faculty

Giancarlo Comi, MD
Professor of Neurology
Director, Department of Neurology
Vita-Salute San Raffaele University
Milan, Italy

Patricia K. Coyle, MD, FAAN, FANA
Professor and Vice Chair (Clinical Affairs)
Department of Neurology
Multiple Sclerosis Comprehensive Care Center
Stony Brook University Medical Center
Stony Brook, NY

Stephen L. Hauser, MD
Director, UCSF Weill Institute for Neurosciences
Professor and Chair, Department of Neurology
University of California, San Francisco
San Francisco, CA

Prof. Xavier Montalban, MD, PhD
Chairman, Department of Neurology-Neuroimmunology
Director, Multiple Sclerosis Centre of Catalonia
Vall d’Hebron University Hospital
Barcelona, Spain

Activity Details

Credit Type: AMA PRA Category 1 Credit
Credit Amount: 1.5
Release Date: December 14, 2016
Expiration Date: December 14, 2017
Estimated Time to Complete Activity: 90 minutes
Registration Required: No
Fee for Activity: There is no fee for participating in this activity.

Provider Statement

This continuing medical education activity is provided by

Support Statement

This activity is supported by an educational grant from Roche.


Prof. Hans-Peter Hartung, MD, FRCP, FAAN, FANA
Consulting Fee: Bayer, Biogen, CSL Behring, GeNeuro, Genzyme, MedImmune, Merck Serono, Novartis, Octapharma, Roche

Giancarlo Comi, MD
Consulting Fee: Almirall, Biogen, Excemed, Forward Pharma, Genzyme, Merck, Novartis, Receptos, Roche, Sanofi, Teva
Non-CME Services Fees: Almirall, Biogen, Excemed, Forward Pharma, Genzyme, Merck, Novartis, Receptos, Roche, Sanofi, Teva
Contracted Research: Biogen, Genzyme, Merck, Novartis, Receptos, Roche, Sanofi, Teva

Patricia K. Coyle, MD, FAAN, FANA
Consulting Fees: Accordant, Bayer, Biogen, Genentech/Roche, Mallincrkrodt, Novartis, Sanofi Genzyme, Serono
Contracted Research: Actelion, Genentech/Roche, Novartis, Opexa

Stephen L. Hauser, MD
Scientific Advisory Board: Annexon, Bionure, Molecular Stethoscope, Neurona, Symbiotix

Prof. Xavier Montalban, MD, PhD
Consulting Fee: Almirall, Bayer, Biogen, Genzyme, Merck, Novartis, Receptos, Roche, Sanofi-Genzyme, Teva

Ronald A. Codario, MD, FACP, FNLA, RPVI, CHCP has no relevant financial relationships to disclose.

Vindico Medical Education staff have no relevant financial relationships to disclose.

Signed disclosures are on file at Vindico Medical Education, Office of Medical Affairs and Compliance.

In accordance with the Accreditation Council for Continuing Medical Education’s Standards for Commercial Support, all CME providers are required to disclose to the activity audience the relevant financial relationships of the planners, teachers, and authors involved in the development of CME content. An individual has a relevant financial relationship if he or she has a financial relationship in any amount occurring in the last 12 months with a commercial interest whose products or services are discussed in the CME activity content over which the individual has control. Relationship information appears above.

Unlabeled and Investigational Usage

The audience is advised that this continuing medical education activity may contain references to unlabeled uses of FDA-approved products or to products not approved by the FDA for use in the United States. The faculty members have been made aware of their obligation to disclose such usage. All activity participants will be informed if any speakers/authors intend to discuss either non-FDA approved or investigational use of products/devices.


Vindico Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation

Vindico Medical Education designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This enduring material is approved for 1 year from the date of original release, December 14, 2016 to December 14, 2017.

How To Participate in this Activity and Obtain CME Credit

To participate in this CME activity, you must read the objectives, answer the pretest questions, read the articles, complete the CME posttest, and complete and return the registration form and evaluation. Provide only one (1) correct answer for each question. A satisfactory score is defined as answering 75% of the posttest questions correctly. Upon receipt of the completed materials, if a satisfactory score on the posttest is achieved, Vindico Medical Education will issue an AMA PRA Category 1 Credit(s)™ Certificate.


Multiple sclerosis (MS), a progressive, immune-mediated inflammatory disease, with debilitating clinical symptoms and worsening of disease activity over time. Multiple sclerosis is characterized by variable clinical courses: relapsing–remitting (RRMS), primary progressive (PPMS), and secondary progressive (SPMS). The differentiation of RRMS from PPMS has been challenging for neurologists, as both diseases share commonalities. Over the last several decades, treatment options have been developed for their effects, mostly on T cells, in the pathogenesis of the disease. Recent evidence has shown that B cells and humoral immunity also play a key role in MS pathogenesis. Early initiation of treatment is imperative to delay progression and provide the best possible outcomes. In this highly interactive CME activity, leading neurologists will review current theories and evidence regarding the immunopathogenesis of MS and assess the mechanisms of action, safety, and efficacy of new therapeutic agents, as well as the latest best practices when using selective high-efficacy agents to treat MS.

To provide an opportunity for practitioners to assure they are up-to-date on the status of and developments in aspects of MS pathology and therapy, Vindico Medical Education is providing this special infographic activity.

Target Audience

The intended audience for this activity is international neurologists and other health care professionals involved in the treatment of patients with MS.

Learning Objectives

Upon successful completion of this educational activity, participants should be better able to:

  • Describe current theories and evidence regarding the immunopathogenesis of multiple sclerosis to better understand how new and emerging therapies may target immunological pathways.
  • Assess the mechanisms of action, safety, and efficacy of new therapeutic agents for the treatment of multiple sclerosis.
  • Apply best practices and clinical evidence when using selective high-efficacy agents to treat relapsing remitting multiple sclerosis to aid in reducing the progression of disease.

Copyright Statement

Created and published by Vindico Medical Education, 6900 Grove Road, Building 100, Thorofare, NJ 08086-9447. Telephone: 856-994-9400; Fax: 856-384-6680. Printed in the USA. Copyright © 2016 Vindico Medical Education. All rights reserved. No part of this publication may be reproduced without written permission from the publisher. The material presented at or in any of Vindico Medical Education continuing medical education activities does not necessarily reflect the views and opinions of Vindico Medical Education. Neither Vindico Medical Education nor the faculty endorse or recommend any techniques, commercial products, or manufacturers. The faculty/authors may discuss the use of materials and/or products that have not yet been approved by the US Food and Drug Administration. All readers and continuing education participants should verify all information before treating patients or utilizing any product.

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