Activity Details

Credit Types:	CME / CNE
Credit Amount:	1.0 AMA PRA Category 1 Credit™
Release Date:	2011-Sep-02
Expiration Date:	2012-Sep-02
Estimated Time for Completion:	1 hour
Registration Required:	No
Cost:	There is no fee to participate in this activity.

Activity Description
A mini website with 2 parts. A downloadable monograph, the other a series of short (5–10 minutes) slide/audio presentations, each delivered by a member of Faculty.

Agenda
The presentations and Monograph discuss the following:

• Gastric cancer: Epidemiology
• HER2 in gastric cancer: Rationale and clinical results
• HER2 testing: When/what samples/what test
• HER2 assays: Scoring standards and critical differences to breast cancer
• Clinical tips for effective integration of HER2 therapy
• Emerging strategies

(either as chapters or presentations)

Goals of Program
Approximately 20-25% of patients with gastric cancer have tumors which are HER2 positive. In this group, molecularly targeted therapy with trastuzumab added to cytotoxic chemotherapy improves overall survival and progression-free survival. However, accurate assessment of HER2 status requires adoption of specific guidelines for sample collection, testing and scoring which vary from those recommended for breast cancer. This program will discuss how HER2 testing and HER2 targeted therapy should be incorporated into clinical care paradigms. This discussion will include the timing of sample collection, the methodology that should be adopted (IHC vs FISH), interpretation of results, and how these may be affected by the sample tested (biopsy or resection).

Learning Objectives
After completing this activity, the participant should be better able to:

• Describe the efficacy of HER2 targeted therapy in gastric cancer
• Evaluate methods for testing HER2 expression in gastric cancer, including type of specimen and required scoring standards
• Identify how HER2 targeted therapy should be integrated into current management of gastric cancer

Target Audience
The educational design of these activities addresses the needs of clinicians, pathologists and nurses involved in the treatment of patients with gastric cancer.

Requirements for Successful Completion
Presentations
In order to receive credit for this activity, the participant must complete the online post-test, achieving a passing score of 70% or greater and evaluation form. This will be automatically sent to Global for processing. You should receive your certificate within 4-6 weeks.

Requirements for Successful Completion
Monograph
In order to receive credit for this activity, the participant must complete the post-test, achieving a passing score of 70% or greater and evaluation form and send these to Global for processing. You should receive your certificate within 4-6 weeks.

Conflict of Interest Policy / Disclosure Statement
Faculty
Global Education Group (Global) requires instructors, planners, managers and other individuals and their spouse/life partner who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Global for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:

Faculty
Axel Grothey, MD
Professor of Oncology
Consultant in the Division of Medical Oncology
The Mayo Clinic
Rochester, MN

Disclosure
Grant/Research Support (awarded to Mayo Foundation)
Genentech, Roche, Daiichi, Bayer

Jeffrey S. Ross, MD - View Biography
Cyrus Strong Merrill Professor and Chair
Department of Pathology and Laboratory Medicine
Albany Medical College
Albany, NY

Disclosure
Consultant Independent Contractor
Foundation Medicine, Inc.
GenPath BRL
Dako
Speaker’s Bureau
Genentech, Inc.
Grant Research Support
Foundation Medicine, Inc.
Honoraria
Genentech, Inc.
Stock Shareholder
Foundation Medicine, Inc.
Syfr, Inc.
Other/Royalties
Various textbooks

Conflict of Interest Policy / Disclosure
Planners/Managers
The planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:

Ian Morgan, MSc
Planner/Manager
Nothing to disclose

Jackie Dawson, MSN
Planner/Manager
Nothing to disclose

Amanda Glazar, PhD
Planner/Manager
Nothing to disclose

Accreditation Statement for Physicians
This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of Global Education Group (Global) and Strategic Consultants International. Global is accredited by the ACCME to provide continuing medical education for physicians. Global Education Group designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Accreditation Statement for Nurses
This educational activity for 1.0 contact hour is provided by Global Education Group. Global Education Group is an approved provider of continuing nursing education by the Colorado Nurses Association, an accredited approver by the American Nurses Credentialing Center’s Commission on Accreditation. Nurses may only earn full credit for this activity, no partial credit will be awarded.

Statement of Commercial Support
Supported by an educational grant from Genentech

Disclaimer Statement
Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group (Global) and Strategic Consultants International do not recommend the use of any agent outside of the labelled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Contact Information for Questions about the Activity
For questions about the accreditation of this activity, please contact Global at (303) 395-1782 or inquire@globaleducationgroup.com.

Hardware / Software Requirements
Presentations: The presentations require Adobe Flash player 9 or greater. This can be downloaded from the Adobe website.
Monograph: The monograph requires Adobe Acrobat Reader. This can be downloaded from the Adobe website.


This activity is jointly sponsored by Global Education Group and Strategic Consultants International.


This activity is supported by an educational grant from Genentech.