Course Director

Jame Abraham
Jame Abraham, MD

Breast Oncology Program
Taussig Cancer Institute
Cleveland Clinic Multidisciplinary Breast Cancer Program
Cleveland Clinic, Cleveland, OH


G. Thomas Budd, MD

Department of Hematology/Medical Oncology
Taussig Cancer Institute
Cleveland Clinic
Professor of Medicine
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University
Cleveland Clinic
Cleveland, OH

Maura N. Dickler

Breast Cancer Medicine Service
Memorial Sloan-Kettering Cancer Center
New York, New York, USA

Richard S. Finn
Richard S. Finn, MD

Geffen School of Medicine at UCLA
Los Angeles, California, USA

Gabriel N. Hortobagyi

Department of Molecular and Cellular Oncology
The University of Texas, M.D. Anderson Cancer Center
Houston, Texas, USA

Accredited by

Cleveland Clinic Center for Continuing Education

View Activity Materials

Course Description

Learning Objectives
1. Identify the current standard of care for endocrine therapy in patients with hormone receptor-positive advanced breast cancer
2. Discuss key results of clinical trials of fulvestrant, alone and in combination regimens, for treatment of HR-positive disease
3. State the mechanism of action of CDK4/6 inhibitors and rationale for their use in HR-positive advanced breast cancer
4. Assess the efficacy and safety of CDK4/6 inhibitors observed in recent clinical trials in women with HR-positive, HER2-negative breast cancer and its potential to overcome endocrine resistance
5. Explain the rationale for use of mTOR inhibitors for treatment of patients with HR-positive advanced breast cancer, and summarize recent clinical trial data supporting the efficacy of such agents in this patient population
6. Review biomarker driven decision making in adjuvant and extended adjuvant setting

Activity Details

Credit Types:CME
Credit Amount:1.25 Credits
Release Date:2017-Aug-23
Expiration Date:2019-Aug-23
Estimated Time for Completion:1 hour 15 minutes
Registration Required:No

Suggest a CME Activity

Please provide below the URL and description of an activity you would like to add to OpenCME. You are welcome to add activities as often as you like. To prevent spam or other abuse, activities are reviewed by our editorial team before appearing on OpenCME.

OpenCME for Publishers

Please use the form below if you would like to offer your website visitors high-quality CME content by adding the OpenCME Widget to one or more of your pages.

Send Email to a Colleague

To share this activity with one or more colleagues, enter their e-mail addresses below. To include a personal message, simply overwrite the suggested text below.

(So your recipient knows it's from you.)
Enter multiple recipients separated by a space.
Optionally, replace/modify in the box above the message that will be sent to your colleague(s) with a link to download this app.