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We would very much appreciate any thoughts you may have about OpenCME and how it could be made more useful for physicians like you.
We would very much appreciate any thoughts you may have about OpenCME and how it could be made more useful for physicians like you.
Charles E. Schmidt College of Medicine,
Florida Atlantic University, Boca Raton, Florida
Department of Pediatrics, Neonatology,
and Adolescent Medicine, Rudolfstiftung Hospital,
Teaching Hospital of the Medical University of Vienna,
Vienna, Austria
ClearlyDerm Center for Dermatology,
Department of Clinical Biomedical Science,
Florida Atlantic University, Boca Raton, Florida
A definitive diagnosis of Langerhans cell histiocytosis (LCH) requires a combination of clinical presentation, histology, and immunohistochemistry. The inflammatory infiltrate contains various proportions of LCH cells, the disease hallmark, which are round and have characteristic “coffee-bean” cleaved nuclei and eosinophilic cytoplasm. Positive immunohistochemistry staining for CD1a and CD207 (langerin) are required for a definitive diagnosis. Isolated cutaneous disease should only be treated when symptomatic, because spontaneous resolution is common. Topical steroids are first-line treatment for localized disease of skin and bone. For multifocal single-system or multisystem disease, systemic treatment with steroids and vinblastine for 12 months is the standard first-line regimen. Current research is seeking more effective regimens because recurrence rates, which increase the risk of sequelae, are still high (30-50%) in patients with multisystem disease. An active area of research is the use of targeted therapy directed at the mitogen-activated protein kinase pathway. Adequate follow-up to monitor for disease progression, relapse, and sequelae is recommended in all patients.
Credit Types: | CME |
Credit Amount: | 1.00 Credits |
Release Date: | 2018-Jun-01 |
Expiration Date: | 2021-Jun-01 |
Estimated Time for Completion: | 1 hour |
Registration Required: | Yes |
Cost: | $35.95 |
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