Jolie Krooks, BS

Charles E. Schmidt College of Medicine,
Florida Atlantic University, Boca Raton, Florida

Milen Minkov, MD, PhD

Department of Pediatrics, Neonatology,
and Adolescent Medicine, Rudolfstiftung Hospital,
Teaching Hospital of the Medical University of Vienna,
Vienna, Austria

Angela G. Weatherall, MD

ClearlyDerm Center for Dermatology,
Department of Clinical Biomedical Science,
Florida Atlantic University, Boca Raton, Florida

Accredited by

American Academy of Dermatology

Course Description

Langerhans cell histiocytosis (LCH) is an inflammatory neoplasia of myeloid precursor cells driven by mutations in the mitogen-activated protein kinase pathway. When disease involves the skin, LCH most commonly presents as a seborrheic dermatitis or eczematous eruption on the scalp and trunk. Evaluation for involvement of other organ systems is essential, because 9 of 10 patients presenting with cutaneous disease also have multisystem involvement. Clinical manifestations range from isolated disease with spontaneous resolution to life-threatening multisystem disease. Prognosis depends on involvement of risk organs (liver, spleen, and bone marrow) at diagnosis, particularly on presence of organ dysfunction, and response to initial therapy. Systemic treatment incorporating steroids and cytostatic drugs for at least one year has improved prognosis of multisystem LCH and represents the current standard of care.

Activity Details

Credit Types:CME
Credit Amount:1.00 Credits
Release Date:2018-Jun-01
Expiration Date:2021-Jun-01
Estimated Time for Completion:1 hour
Registration Required:Yes

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