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Activity Details

Free CME
1.0 AMA PRA Category 1 Credit(s)
Released: March 31, 2020
Expires: March 30, 2021
1 hour to complete

Accredited By

This continuing medical education activity is provided by

Target Audience

The intended audience for this activity is neurologists, neuromuscular specialists, pediatricians, and other health care professionals involved in the management of patients with limb-girdle muscular dystrophies (LGMD).

Learning Objectives

Upon successful completion of this activity, participants should be better able to:
  • Evaluate the genetic and molecular causes of the major subtypes of LGMD as well as the clinical implications for patients.
  • Examine the heterogeneity in symptoms experienced by patients with LGMD and the implications for patient management.
  • Assess appropriate tests and medical work-up to aid in the timely and accurate subtype diagnosis for patients with LGMD.

Activity Description

Limb girdle muscular dystrophies (LGMD) are a group of rare neuromuscular disorders characterized by weakness and wasting of the muscles in the shoulder and pelvic girdles. The severity, age of onset, and heterogeneity are determined by mutations in various genes. To date, there are no disease-modifying options for patients with LGMD; instead, management is based on multidisciplinary care to treat the symptoms and prevent further progression. As the science surrounding LGMD and its treatment continues to evolve, it is imperative that neurologists and other providers understand the mechanisms of disease, the difference in subtypes, and how to achieve accurate diagnosis. To address these topics, experts on LGMD will present a web-based educational activity featuring multidisciplinary perspectives.

Agenda

  • Introduction
  • Limb Girdle Molecular Dystrophies - Prevalence and Symptoms
  • Genetic Causes of LGMD - Implications for Disease Heterogeneity and Diagnosis
  • Achieving Accurate Subtype Diagnosis in LGMD - A Discussion of Best Practices
  • Conclusion

Activity Chair

Matthew P. Wicklund, MD
Professor of Neurology
University of Colorado School of Medicine
Aurora, CO

Disclosure:
Consulting Fee: Sarepta
Contracted Research: Muscular Dystrophy Association
Ownership Interest: Myonexuss

Faculty

Nicholas Johnson, MD, MSCI
Vice Chair of Research
Associate Professor
Virginia Commonwealth University
Richmond, VA

Disclosure:
Intellectual Property/Patent Details: University of Rochester
Consulting Fee: AskBio, AveXis, Dyne, ML Bio Solutions, Sarepta, Triplett, Vertex
Contracted Research: AveXis, ML Bio Solutions, Sarepta, Vertex
Ownership Interest: ML Bio Solutions


Monkol Lek, PhD
Assistant Professor
Yale University School of Medicine
New Haven, CT

Disclosure:
No relevant financial relationships to disclose.


Katherine D. Mathews, MD
Professor, Departments of Pediatrics and Neurology
Vice Chair for Clinical Research, Department of Pediatrics
University of Iowa Carver College of Medicine
Iowa City, IA

Disclosure:
Consulting Fee (paid to institution): Asklepios, AveXis, Santhera, Sarepta
Contracted Research: Hoffmann-La Roche, Pfizer, PTC Therapeutics, Santhera, Sarepta, Wave

Reviewer
Ronald A. Codario, MD, EMBA, FACP, FNLA, RPVI, CHCP

  • Disclosure: No relevant financial relationships to disclose.

Vindico Medical Education Staff

  • Disclosure: No relevant financial relationships to disclose.

Signed Disclosures are on file at Vindico Medical Education, Office of Medical Affairs and Compliance.

Conflict of Interest Policy/Disclosure Statement

In accordance with the Accreditation Council for Continuing Medical Education’s Standards for Commercial Support, all accredited providers are required to mitigate and disclose to the activity audience the relevant financial relationships of the planners, teachers, and authors involved in the development of accredited content. An individual has a relevant financial relationship if he or she has a financial relationship in any amount occurring in the past 12 months with a commercial interest whose products or services are discussed in the accredited activity content over which the individual has control. Relationship information appears above.

Accreditation Statement

Vindico Medical Education is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Designation of Credit

Vindico Medical Education designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Instructions for Receiving Credit

To participate in this CME activity, you must read the objectives, answer the pretest questions, view the CME content, and complete the posttest and evaluation. Provide only one (1) correct answer for each question. A satisfactory score is defined as answering 66% of the posttest questions correctly. Upon receipt of the completed materials, if a satisfactory score on the posttest is achieved, Vindico Medical Education will issue an AMA PRA Category 1 Credit(s)™ Certificate.

Statement of Commercial Support

This activity is supported by an educational grant from Sarepta Therapeutics, Inc.

Disclaimer Statement/Disclosure of Unlabeled Use

The audience is advised that this continuing medical education activity may contain references to unlabeled uses of FDA-approved products or to products not approved by the FDA for use in the United States. The faculty members have been made aware of their obligation to disclose such usage. All activity participants will be informed if any speakers/authors intend to discuss either non–FDA-approved or investigational use of products/devices.

Copyright Statement

Created and published by Vindico Medical Education, 6900 Grove Road, Building 100, Thorofare, NJ 08086-9447. Telephone: 856-994-9400; Fax: 856-384-6680. Printed in the USA. Copyright © 2020 Vindico Medical Education. All rights reserved. No part of this publication may be reproduced without written permission from the publisher. The material presented at or in any of Vindico Medical Education continuing medical education activities does not necessarily reflect the views and opinions of Vindico Medical Education. Neither Vindico Medical Education nor the faculty endorse or recommend any techniques, commercial products, or manufacturers. The faculty/authors may discuss the use of materials and/or products that have not yet been approved by the US Food and Drug Administration. All readers and continuing education participants should verify all information before treating patients or utilizing any product.

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