Clyde E. Markowitz, MD
Clyde E. Markowitz, MD
Associate Professor of Neurology
Hospital of the University of Pennsylvania
Philadelphia, PA

Gregory F. Wu, MD, PhD
Gregory F. Wu, MD, PhD
Assistant Professor, Neurology
Division of Adult Neurology
Washington University in St Louis
St Louis, MO

Accredited By

This activity is jointly provided by Global Education Group and Strategic Consultants International (SCI)

Activity Details

Credit Type: AMA PRA Category 1 Credit
Credit Amount: 0.75
Release Date: September 26, 2016
Expiration Date: September 26, 2017
Estimated Time to Complete Activity: 45 minutes
Registration Required: No
Fee for Activity: There is no fee for this educational activity

Activity Description

This activity is a 2-part presentation focusing on the role of B cells in the pathogenesis of MS and the rationale of targeting B cells to attenuate the immune system in MS.  Clinical data of therapies targeting B cells will be discussed which provide supportive evidence for a role in immunopathology of B cells in both relapsing and progressive forms of the disease. Clinical trial endpoints will also be critically evaluated to consider how targeting B cells may influence the management of patients with MS.

Statement of Educational Need

There is a substantial body of evidence indicating that B cells play a role in the development of MS and therapies targeting B cells are now being assessed in clinical trials for both progressive and relapsing MS. For patients with progressive MS, there are currently no approved treatments proven to slow disease progression. This relates to an incomplete understanding of the disease pathogenesis, lack of validated outcome measures and mostly negative clinical trial experience to date. 

Therefore, there is a need for neurologists and other healthcare providers to be educated regarding some of the recent advances in MS, including the pathophysiology of MS and the role of B cells, and an overview of clinical trial data for therapies which target B cells.


Part 1: Novel perspectives on pathology and therapeutic targets (Gregory Wu)

Part 2: Targeting B cells in MS: Concept to clinic (Clyde Markowitz)

Learning Objectives

After completing this activity, the participant should be better able to:

  • Discuss the pathophysiology of progressive MS and how it differs from relapsing-remitting MS
  • Review the role of B cells in the immunopathology of MS
  • Assess the use of endpoints in clinical trials of DMTs for MS and impact this can have on outcomes
  • Review the clinical trial evidence for B cell targeting therapy in MS and how this may affect clinical outcomes

Target Audience

The educational design of this activity addresses the needs of physicians and MS nurses involved in the treatment of patients with multiple sclerosis (MS). Other healthcare providers may also find this program of interest.

Conflict of Interest Policy / Disclosure Statement

Disclosure of Conflicts of Interest
Global Education Group (Global) requires instructors, planners, managers and other individuals and their spouse/life partner who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Global for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:

Name of Faculty or Presenter Reported Financial Relationship
Gregory Wu Consultant: Biogen
Grant/Research Support: NIH
Speaker’s Bureau: Genzyme, Pfizer
Clyde Markowitz Consultant/Advisor: Bayer AG; Biogen; EMD Serono, Inc.; Genentech, Inc.; Genzyme Corporation; Novartis AG; Opexa Therapeutics, Inc.; F. Hoffmann-La Roche Ltd; Teva Pharmaceutical Industries Ltd

The planners and managers reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of this CME activity:

Name of Planner or Manager Reported Financial Relationship
Amanda Glazar, PhD Nothing to disclose
Andrea Funk Nothing to disclose
Laura Gilsdorf Nothing to disclose
Ian Morgan Nothing to disclose
Elena Urso Nothing to disclose

Accreditation Statement

Physician Accreditation Statement
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Global Education Group (Global) and Strategic Consultants International (SCI). Global is accredited by the ACCME to provide continuing medical education for physicians.

Nursing Continuing Education
Global Education Group is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s COA.

Designation of Credit

Physician Credit Designation
Global Education Group designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Credit Designation
This educational activity for 0.75 contact hours is provided by Global Education Group. Nurses should claim only the credit commensurate with the extent of their participation in the activity.

Instructions for Receiving Credit

In order to receive credit for this activity, the participant must review the materials, complete the post-activity test with a pass mark of 70% or greater and complete the evaluation and credit request.

Statement of Commercial Support

This activity is supported by an educational grant from Genentech, Inc.

Disclaimer Statement / Disclosure of Unlabeled Use

Disclosure of Unlabeled Use
This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group (Global) and Strategic Consultants International (SCI) do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Contact Information for Questions about the Activity

Global Contact Information
For information about the accreditation of this program, please contact Global at 303-395-1782 or

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