John J. Strouse, MD, PhD
John J. Strouse, MD, PhD (Course Director)
Assistant Professor of Pediatrics and Medicine
Johns Hopkins University School of Medicine
Division of Pediatric Hematology
Baltimore, Maryland 

Stacy E. Croteau, MD, MMS
Stacy E. Croteau, MD, MMS
Instructor in Pediatrics
Harvard Medical School
Associate Director
Boston Hemophilia Center
Boston, Massachusetts

Dr Croteau reports receiving grants/research support from Baxalta US Inc;
and serving as a consultant/advisor for Baxalta US Inc, Bayer, CSL Behring,
Dimension Therapeutics Inc, Novo Nordisk, Octapharma, and Pfizer Inc.

Michelle N. Eakin, PhD
Michelle N. Eakin, PhD
Assistant Professor
Division of Pulmonary and Critical Care Medicine
Johns Hopkins University School of Medicine 
Baltimore, Maryland 

No other speakers have indicated that they have any financial interests or
relationships with a commercial entity whose products or services are relevant to
the content of their presentation(s).


No other planners have indicated that they have any financial interests or relationships with a commercial entity.

Note: Grants to investigators at The Johns Hopkins University are negotiated and administered by the institution which receives the grants, typically through the Office of Research Administration. Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor, but may receive salary or other support from the institution to support their effort on the project(s).

OFF-LABEL PRODUCT DISCUSSION – No speaker has indicated that he/she will reference unlabeled/unapproved uses of drugs or  products.

Presented by the Johns Hopkins University School of Medicine.

Activity Details

Credit Type: ACCME
Credit Amount: 1.5
Release Date: July 7, 2016
Expiration Date: July 7, 2018
Estimated Time to Complete Activity: 90 minutes
Registration Required: No
Fee for Activity: There is no fee for this educational activity.

Activity Description

A web-based archived live symposium

Statement of Educational Need

The recent introduction of new bioengineered Factor VIII and Factor IX replacement therapies with longer half-lives are expected to have profound implications on prophylaxis treatment regimens for patients being treated for hemophilia. The decreased frequency of infusions with these bioengineered therapies is expected to facilitate individualized treatment plans that will incorporate patient-specific targeted trough levels, reducing risk of breakthrough bleeds. Prophylaxis can protect against joint disease and allow a hemophilia patient to live a normal life with an average life expectancy, but the key to its effectiveness is early implementation and good adherence. This archived symposium will review the principles of pharmacokinetic-based factor replacement therapy, including its potential advantages and disadvantages as prophylaxis versus on-demand therapy. Because adherence is the cornerstone of effective prophylaxis, effective methods to measure and increase adherence that can be practically implemented in a busy clinical setting will be discussed.


Preassessment and Activity Goals
John J. Strouse, MD, PhD

Pharmacokinetic-Based Factor Replacement to Optimize Prophylactic and Therapeutic Treatment of Hemophilia
Stacy E. Croteau, MD, MMS

Clinician Interventions to Improve Adherence to Hemophilia Treatment
Michelle N. Eakin, PhD

Question & Answer Session
John J. Strouse, MD, PhD

Postassessment and Evaluation

Goals (Purpose) of Program

This archived live symposium will provide clinicians who treat patients with hemophilia A or B with up-to-date information on pharmacokinetic-based factor replacement when used as prophylaxis and, because prophylaxis relies on optimal adherence, practical methods to measure and address adherence issues. 

Learning Objectives

After participating in this activity, the participant will demonstrate the ability to:

  • DESCRIBE the role of pharmacokinetic-based therapy in the management of children and adults with hemophilia.
  • IMPLEMENT PK-based therapy for patients with hemophilia.
  • DESCRIBE clinician interventions to identify and address medication nonadherence in the management of patients with hemophilia.
  • INCORPORATE rapid methods to measure adherence to therapy in the management of patients of hemophilia.

The Johns Hopkins University School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity. 

Target Audience

This activity has been designed to meet the needs of adult and pediatric physicians in hematology settings, as well as other appropriate healthcare providers (including orthopedists, dentists, nurse practitioners and physicians’ assistants) who care for patients with hemophilia. There are no prerequisites.

Requirements for Successful Completion

In order to receive credit, participants must complete the pre-test, review the online activity, complete the post-test and receive a score of at least 70%, and complete the evaluation. A certificate of participation will be available online immediately following successful completion of the activity.


Online Activity

Conflict of Interest Policy / Disclosure Statement

Full Disclosure Policy Affecting CME Activities
As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), it is the policy of the Johns Hopkins University School of Medicine Office of Continuing Medical Education (OCME) to require signed disclosure of the existence of financial relationships with industry from any individual in a position to control the content of a CME activity sponsored by OCME. Members of the Planning Committee are required to disclose all relationships regardless of their relevance to the content of the activity. Faculty are required to disclose only those relationships that are relevant to their specific presentation. 

Accreditation Statement

The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Designation of Credit

The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Statement of Commercial Support

Supported by an educational grant from Biogen.

Disclaimer Statement / Disclosure of Unlabeled Use

Off-Label Product Discussion
No speaker has indicated that he/she will reference unlabeled/unapproved uses of drugs or products.

The opinions and recommendations expressed by faculty and other experts whose input is included in this program are their own. This enduring material is produced for educational purposes only. Use of Johns Hopkins University School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.

I certify that I am attending a Johns Hopkins University School of Medicine CME activity for accredited training and/or educational purposes.

I understand that while I am attending in this capacity, I may be exposed to "protected health information," as that term is defined and used in Hopkins policies and in the federal HIPAA privacy regulations (the “Privacy Regulations”). Protected health information is information about a person's health or treatment that identifies the person. 

I pledge and agree to use and disclose any of this protected health information only for the training and/or educational purposes of my visit and to keep the information confidential. I agree not to post or discuss this protected health information, including pictures and/or videos, on any social media site (eg, Facebook, Twitter, etc), in any electronic messaging program or through any portable electronic device.

I  understand that I may direct to the Johns Hopkins Privacy Officer any questions I have about my obligations under this  Confidentiality  Pledge or under any of the Hopkins policies  and procedures  and  applicable  laws  and  regulations  related  to  confidentiality. The contact information is: Johns Hopkins Privacy Officer, telephone: 410-735-6509, e-mail:

“The Office of Continuing Medical Education at the Johns Hopkins University School of Medicine, as provider of this activity, has relayed information with the CME attendees/participants and certifies that the visitor is attending for training, education and/or observation purposes only.”

For CME Questions, please contact the CME Office at 410-955-2959 or e-mail For CME Certificates, please call 410-502-9634.

Johns Hopkins University School of Medicine Office of Continuing Medical Education
Turner 20/720 Rutland Avenue
Baltimore, Maryland

Reviewed & Approved by:
General Counsel, Johns Hopkins Medicine (4/1/03)
(Updated 4/09 and 3/14)

Contact Information for Questions about the Activity

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