James A. Underberg, MD, MS, FACPM, FACP, FASH, FNLA, FASPC

Clinical Assistant Professor of Medicine
NYU School of Medicine &
NYU Center for Prevention of Cardiovascular Disease
Director, Bellevue Hospital Lipid Clinic
NYU Langone Medical Center & Bellevue Hospital Center
New York, New York

Accredited By

Activity Details

Credit Type: CME/CNE/CPE
Credit Amount: 1.0 credit hour
Release Date: September 23, 2016
Expiration Date: September 23, 2017
Estimated Time to Complete Activity: 1 hour
Registration Required: No
Fee for Activity: There is no fee associated with this activity.

Intended Learners

This activity is designed for cardiologists and cardiology-related healthcare professionals including residents, fellows, nurse practitioners, physician assistants, pharmacists, nurses and other healthcare professionals involved in the care of patients with hypercholesterolemia.

Learning Objectives

After completing this activity, participants should be able to:

  • Review clinical evidence that supports a treat-to-target approach to hypercholesterolemia management
  • Discuss the latest clinical trial data for PCSK9 inhibitors in various patient groups, including its mechanisms-of-action, safety, efficacy, administration, and indications
  • Identify appropriate patient candidates for the aggressive lowering of LDL-C utilizing PCSK9 inhibitors
  • Translate clinical trial data of PCSK9 inhibitors to the individualized and targeted management approach of high risk hypercholesterolemia patients

Activity Overview

This on-demand webcast is available with synchronized slides and video.

To be eligible for documentation of credit, participants must complete the educational activity, complete the 10-question post-test with a score of 70% or better, and complete the evaluation form. After successful completion of the post-test and evaluation form online at, participants may immediately print their documentation of credit.

Release date: September 23, 2016
Expiration date: September 23, 2017
Estimated time to complete: 1 hour

There is no fee associated with this activity.

Participants who completed the live version of this activity are not eligible to receive credit for this enduring material.

For questions regarding this educational activity, please call 609-371-1137.

ACPE Credit Policy

Your official record of ACPE credit will be generated through the CPE Monitor System. The certificate printed from this website after completing the evaluation for this activity is for personal tracking purposes only.

Eligibility for pharmacy credit is contingent upon the successful completion of a post-test and/or evaluation for each activity or session attended. Please note that you must complete the activity evaluation within 60 days of a live activity or within 60 days of beginning the evaluation for an enduring activity. Under ACPE Policy, NACCME will not be able to report your activity completion to CPE Monitor after this 60-day period.

Hardware / Software Requirements

All educational activities are accessible via a PC (Windows 2000/XP/Vista/7) or Mac (Mac OS 10.x or later) computer with current versions of the following browsers: Internet Explorer, Mozilla Firefox, Google Chrome, or Safari. Windows Media Player or compatible alternative, sound card, and speakers are required for streamed audio. The latest version of the Adobe Flash Player is suggested for video programs (please download here). A PDF reader is required for print publications. Please direct technical questions to


North American Center for Continuing Medical Education, LLC (NACCME) is accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

NACCME designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

This continuing nursing education activity awards 1.0 contact hour.

Provider approved by the California Board of Registered Nursing, Provider #13255 for 1.0 contact hour.

This activity is approved for 1.0 contact hour (.1 CEU) of continuing pharmacy education (UAN: 0276-0000-16-127-H01-P).

This educational activity is a knowledge-based activity.

Any participant wanting to file a grievance with respect to any aspect of a continuing pharmacy education activity accredited by NACCME may contact the Senior Manager, Accreditation & Compliance, NACCME, in writing at 104 Windsor Center Drive, East Windsor, NJ 08520. The Senior Manager, Accreditation & Compliance will review the grievance and respond within 30 days of receiving the written statement. If the participant is unsatisfied with the response, an appeal to the Senior Director, Accreditation and Compliance, NACCME, may be made for a second level of review.

Independent Clinical Reviewer: Peter Oettgen, MD, FACC, FAHA, FACP, Director of Preventive Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Associate Professor of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts

Nurse Planner: Susie Seaman, NP, Sharp Rees-Stealy Wound Clinic, San Diego, California

Planning Committee:
The planning committee comprises Peter Oettgen, MD, FACC, FAHA, FACP, Susie Seaman, NP, James A. Underberg, MD, MS, FACPM, FACP, FASH, FNLA, FASPC; and Donna Brophy, Jennifer Browne, Celeste Collazo, MD, Mary Johnson, Mike Kearney, Tanya Kenevich, Michelle Montgomery, Randy Robbin, and John Savage, NACCME.

Financial Disclosure and Conflicts of Interest

According to the disclosure policy of NACCME, faculty, editors, managers, and other individuals who are in a position to control content are required to disclose any relevant financial relationships with relevant commercial companies related to this activity. All relevant conflicts of interest that are identified are reviewed for potential conflicts of interest. If a conflict is identified, it is the responsibility of NACCME to initiate a mechanism to resolve the conflict(s). The existence of these interests or relationships is not viewed as implying bias or decreasing the value of the presentation.

All educational materials are reviewed for fair balance, scientific objectivity of studies reported, and levels of evidence.

The faculty has reported the following:
Ms. Seaman: Scientific advisor—Smith & Nephew, Inc.; Promotional Speakers’ Bureau—Smith & Nephew, Inc.

Dr. Underberg: Board Member—National Lipid Association, FH Foundation (Scientific Advisory Board Member), Foundation of the National Lipid Association, American Board of Clinical Lipidology; Consultant—Amgen; Grant/Research Support—Aegerion, Pfizer; Promotional Speakers’ Bureau—Alexion, Amgen, Merck, Regeneron, Sanofi; Scientific Advisor—Aegerion, Akcea, Alexion, Amgen, Astra Zeneca, Gemphire, Invitae, Merck, Regeneron, Sanofi

Dr. Oettgen has disclosed no relevant financial relationships with any commercial interest.

Ms. Brophy, Ms. Browne, Dr. Collazo, Ms. Johnson, Mr. Kearney, Ms. Kenevich, Ms. Montgomery, Mr. Robbin, and Mr. Savage have disclosed no relevant financial relationships with any commercial interests.

NACCME requires faculty to inform participants whenever off-label/unapproved uses of drugs and/or devices are discussed in their presentations.

The faculty have disclosed that no off-label/unapproved drugs and/or devices will be discussed.

Grant Support

Supported by educational funding provided by Amgen and Sanofi US and Regeneron Pharmaceuticals.

Privacy Policy

NACCME protects the privacy of personal and other information regarding participants, educational partners, and joint sponsors. NACCME and our joint sponsors will not release personally identifiable information to a third party without the individual’s consent, except such information as is required for reporting purposes to the appropriate accrediting agency.

NACCME maintains physical, electronic, and procedural safeguards that comply with federal regulations to guard your nonpublic personal information.

Copyright © 2016 by North American Center for Continuing Medical Education, LLC. All rights reserved. No part of this accredited continuing education activity may be reproduced or transmitted in any form or by any means, electronic or mechanical, without first obtaining permission from North American Center for Continuing Medical Education. The opinions expressed in this educational activity are those of the faculty and are not attributable to NACCME. Clinical judgment must guide each professional in weighing the benefits of treatment against the risk of toxicity. Dosages, indications, and methods of use for products referred to in this activity are not necessarily the same as indicated in the package insert for each product, may reflect the clinical experience of the presenters, and may be derived from the professional literature or other clinical sources. Consult complete prescribing information before administering.

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