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Course Director

Stephan A. Grupp, MD, PhD
Stephan A. Grupp, MD, PhD

University of Pennsylvania Perelman School of Medicine
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania

Faculty

Krishna Komanduri
Krishna Komanduri, MD

Sylvester Comprehensive Cancer Center
University of Miami
Miami, Florida

Accredited by

The Medical College of Wisconsin

Activity Details

Credit Types:CME
Credit Amount:1.0 Credits
Release Date:2018-Apr-05
Expiration Date:2019-Apr-04
Estimated Time for Completion:60 minutes
Registration Required:No
Cost:Free of Charge

Activity Description and Educational Objectives

In this activity, experts in the management of hematologic malignancies discuss the science behind adoptive immunotherapy with chimeric antigen receptor (CAR)-T cell therapy and exciting new developments with this innovative treatment approach for patients with leukemia and B-cell lymphoma, including the latest efficacy and safety data, recent indications for use of different CAR-T cell constructs, and their role in the context of HCT. These experts also provide insight on practical considerations for appropriate integration of CAR-T cell therapies into treatment plans, identifying patients most likely to benefit from these agents, and strategies for managing unique CAR-T cell–related toxicities.

Upon completion of this activity, participants should be better able to:
  • Discuss the anticancer mechanisms and the latest evidence on efficacy and safety of adoptive immunotherapy with CAR-T cells in various lymphoma and leukemia settings
  • Identify the clinical role of and patients that might benefit from CAR-T cell therapy in conjunction with current treatment paradigms including HCT for leukemia and lymphoma
  • Describe strategies for managing the unique safety issues associated with the use of CAR-T cell therapy

Target Audience

This activity has been designed to meet the educational needs of hematologist-oncologists, oncologists, BMT specialists, BMT nurse specialists, and other clinicians involved in the management of patients with lymphomas or leukemias.

Requirements for Successful Completion

In order to receive credit, participants must view the activity and complete the post-test and evaluation form. There are no pre-requisites and there is no fee to participate in this activity or to receive CME credit. Statements of Credit are awarded upon successful completion of the post-test and evaluation form.

Media: Enduring Material
Release and Expiration Dates: April 05, 2018 - April 04, 2019
Time to Complete: 60 minutes

Faculty & Disclosure / Conflict of Interest Policy

In accordance with ACCME requirements, The Medical College of Wisconsin has a conflict of interest policy that requires faculty to disclose relevant financial relationships related to the content of their presentations/materials. Any potential conflicts are resolved so that presentations are evidence-based and scientifically balanced.

Course Director and Moderator

Stephan A. Grupp, MD, PhD
Novotny Professor of Pediatrics
University of Pennsylvania Perelman School of Medicine
Chief, Cellular Therapy and Transplant Section
Director, Cancer Immunotherapy Frontier Program
CCCR Director of Translational Research
The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania

Stephan A. Grupp, MD, PhD, has a financial interest/relationship or affiliation in the form of:
Consultant for Novartis Pharmaceuticals Corporation.

Faculty

Krishna Komanduri, MD
Kalish Family Chair in Stem Cell Transplantation
Professor of Medicine, Microbiology & Immunology
Director, Adult Stem Cell Transplant Program
Sylvester Comprehensive Cancer Center
University of Miami
Miami, Florida

Krishna Komanduri, MD, has a financial interest/relationship or affiliation in the form of:
Advisory Board for Juno Therapeutics, Inc. and Kite Pharma.
Other Financial or Material Support from Novartis Pharmaceuticals Corporation for Data Monitoring Committee.

Medical Director

Aarati Ranganathan, PhD
PVI, PeerView Institute for Medical Education

Aarati Ranganathan, PhD, has no financial interests/relationships or affiliations in relation to this activity.

The Medical College of Wisconsin (MCW) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by MCW for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

Providership, Credit & Support

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of The Medical College of Wisconsin and PVI, PeerView Institute for Medical Education. The Medical College of Wisconsin is accredited by the ACCME to provide continuing medical education for physicians.

The Medical College of Wisconsin designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Hours of Participation for Allied Health Care Professionals:

The Medical College of Wisconsin designates this activity for up to 1.0 hours of participation for continuing education for allied health professionals.

Providership

This CME activity is jointly provided by The Medical College of Wisconsin and PVI, PeerView Institute for Medical Education.

Support

This activity is supported by educational grants from Kite, A Gilead Company, and Novartis Pharmaceuticals Corporation.

Disclosure of Unlabeled Use

The faculty of this educational activity may include discussions of products or devices that are not currently labeled for use by the FDA. Faculty members have been advised to disclose to the audience any reference to an unlabeled or investigational use.

No endorsement of unapproved products or uses is made or implied by coverage of these products or uses in our reports. No responsibility is taken for errors or omissions in reports. For approved prescribing information, please consult the manufacturer’s product labeling.

The materials presented here are used with the permission of the authors and/or other sources. These materials do not necessarily reflect the views of PeerView or any of its partners, providers, and/or supporters.

About This CME Activity

PVI, PeerView Institute for Medical Education, and The Medical College of Wisconsin are responsible for the selection of this activity’s topics, the preparation of editorial content, and the distribution of this activity. Our activities may contain references to unapproved products or uses of these products in certain jurisdictions. The preparation of PeerView activities is supported by educational grants subject to written agreements that clearly stipulate and enforce the editorial independence of PVI and The Medical College of Wisconsin.

Copyright © 2000-2018, PeerView

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