Andrew Dodson

Academic Department of Biochemistry,
Royal Marsden Hospital, London, UK

Lila Zabaglo

Academic Department of Biochemistry,
Royal Marsden Hospital, London, UK;
The Breakthrough Toby Robins Breast Cancer Research Centre,
Institute of Cancer Research, London, UK

Belinda Yeo

Breast unit research fellow,
Breast Unit, Royal Marsden Hospital,
London, UK

Keith Miller

UK National External Quality Assessment for
Immunocytochemistry and In-situ Hybridisation,
University College London, London, UK

Ian Smith

Breast Unit, Royal Marsden Hospital
Institute of Cancer Research
London, UK

Mitch Dowsett

Academic Department of Biochemistry,
Royal Marsden Hospital, London, UK

Accredited by

BMJ Learning

Course Description

Aims: The IHC4+C score combines assessment of oestrogen receptor (ER), progesterone receptor (PgR), HER2 and Ki67 with clinicopathological parameters to identify the risk of distant disease recurrence in patients with breast cancer, so, aiding treatment decision-making on adjuvant chemotherapy. Despite low cost and wide availability, the reported use of IHC4+C remains limited; one explanation for this is the perception that immunohistochemistry (IHC)-based methods and assessment of them lack precision, reproducibility and portability. We examined the effects of decentralised testing and easily reproducible estimate-based scoring methods on IHC4+C scores to determine its suitability for wider adoption.

Activity Details

Credit Types:CME
Credit Amount:1.00 Credits
Release Date:2015-Aug-03
Expiration Date:2017-Aug-03
Estimated Time for Completion:1 hour
Registration Required:Yes

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