Course Director

Anna F. Farago, MD, PhD
Anna F. Farago, MD, PhD

Massachusetts General Hospital
Harvard Medical School
Boston, Massachusetts

Accredited by

Medical Learning Institute, Inc.

Activity Details

Credit Types:CME / MOC
Credit Amount:1.0 Credits
Release Date:2019-Feb-07
Expiration Date:2020-Feb-06
Estimated Time for Completion:60 minutes
Registration Required:No
Cost:Free of charge

Activity Description and Educational Objectives

In this activity, an expert in oncology and pathology discusses how to identify patients with cancer who may benefit from the use of tumor-agnostic approaches to treatment, such as tropomyosin receptor kinase (TRK) fusion inhibitors, and how to realize the potential clinical benefits of recently approved and emerging strategies targeting TRK fusions in a multitude of cancer patients. The expert will also discuss the importance of appropriately testing cancer patients for the presence of neurotrophic tyrosine receptor kinase (NTRK) gene fusions and basing therapeutic decisions on accurate diagnostic information in the TRK fusion-positive disease setting.

Upon completion of this activity, participants should be better able to:
  • Summarize the rationale for molecular testing for TRK fusions in a range of cancer settings, including head and neck cancer, GI cancers, breast cancer, and lung cancer, among others
  • Identify adult and pediatric patients with cancers that could harbor NTRK gene fusions and who may be candidates for treatment with TRK fusion inhibitors
  • Select appropriate diagnostic testing techniques for confirming the presence of TRK fusions in different solid tumors
  • Interpret molecular profiling results to guide treatment decisions in TRK fusion-positive cancers

Target Audience

This activity has been designed to meet the educational needs of pathologists, oncologists, cytotechnologists, researchers, and other clinicians involved in treating solid tumors.

Requirements for Successful Completion

In order to receive credit, participants must view the activity and complete the post-test and evaluation form. A score of 70% or higher is needed to obtain CME/MOC credit. There are no pre-requisites and there is no fee to participate in this activity or to receive CME/MOC credit. Statements of Credit are awarded upon successful completion of the post-test and evaluation form.

Media: Enduring Material
Release and Expiration Dates: February 07, 2019 - February 06, 2020
Time to Complete: 60 minutes

Faculty and Disclosure / Conflict of Interest Policy

Before the activity, all faculty and anyone who is in a position to have control over the content of this activity and their spouse/life partner will disclose the existence of any financial interest and/or relationship(s) they might have with any commercial interest producing healthcare goods/services to be discussed during their presentation(s): honoraria, expenses, grants, consulting roles, speakers bureau membership, stock ownership, or other special relationships. Presenters will inform participants of any off-label discussions. All identified conflicts of interest are thoroughly vetted by Medical Learning Institute, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

The associates of Medical Learning Institute, Inc., the accredited provider for this activity, and PVI, PeerView Institute for Medical Education do not have any financial relationships or relationships to products or devices with any commercial interest related to the content of this CME/MOC activity during the past 12 months.

Course Director

Anna F. Farago, MD, PhD
Assistant in Medicine
Massachusetts General Hospital
Assistant Professor of Medicine
Harvard Medical School
Boston, Massachusetts

Anna F. Farago, MD, PhD, has a financial interest/relationship or affiliation in the form of:
Consultant for AbbVie Inc.; AstraZeneca; Bayer; Genentech, Inc.; Loxo Oncology; and PharmaMar.
Speakers Bureau participant with Foundation Medicine, Inc.

Anna F. Farago, MD, PhD, does intend to discuss either non-FDA-approved or investigational use for the following products/devices: entredtinib, ropotrectinib; LOXO-195.

Content Reviewers

Tracy L. Greene, MSN, RN, FNP-C, has no financial interests/relationships or affiliations in relation to this activity.

Shaina Rozell, MD, MPH, has no financial interests/relationships or affiliations in relation to this activity.

Medical Director

Carmine DeLuca
PVI, PeerView Institute for Medical Education

Carmine DeLuca has no financial interests/relationships or affiliations in relation to this activity.


The information provided at this CME/MOC activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient's medical condition. Recommendations for the use of particular therapeutic agents are based on the best available scientific evidence and current clinical guidelines. No bias towards or promotion for any agent discussed in this program should be inferred.

Providership, Credit, and Support

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Medical Learning Institute, Inc. and PVI, PeerView Institute for Medical Education. The Medical Learning Institute, Inc. is accredited by the ACCME to provide continuing medical education for physicians.

The Medical Learning Institute, Inc. designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

MOC Statement

The activity titled “The TRK to Tumor-Agnostic Care in Solid Tumors: A Pathology-Focused Guide to the Clinical Role of TRK Fusions in Personalizing Cancer Therapy” has been registered to offer 1.0 Lifelong Learning (Part II) credit in the American Board of Pathology’s (ABPath) Continuing Certification program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABPath MOC credit.

Participation information will be shared with ABPath through the ACCME’s Program and Activity Reporting System (PARS). Blinded individual or aggregated participant data may be shared with the funder of the activity.


This CME/MOC activity is jointly provided by Medical Learning Institute, Inc. and PVI, PeerView Institute for Medical Education.


This activity is supported by an independent educational grant from Bayer and Loxo Oncology.

Disclosure of Unlabeled Use

The faculty of this educational activity may include discussions of products or devices that are not currently labeled for use by the FDA. Faculty members have been advised to disclose to the audience any reference to an unlabeled or investigational use.

No endorsement of unapproved products or uses is made or implied by coverage of these products or uses in our reports. No responsibility is taken for errors or omissions in reports. For approved prescribing information, please consult the manufacturer’s product labeling.

The materials presented here are used with the permission of the authors and/or other sources. These materials do not necessarily reflect the views of PeerView or any of its partners, providers, and/or supporters.

About This CME/MOC Activity

PVI, PeerView Institute for Medical Education, and Medical Learning Institute, Inc. are responsible for the selection of this activity’s topics, the preparation of editorial content, and the distribution of this activity. Our activities may contain references to unapproved products or uses of these products in certain jurisdictions. The preparation of PeerView activities is supported by educational grants subject to written agreements that clearly stipulate and enforce the editorial independence of PVI and Medical Learning Institute, Inc.

Copyright © 2000-2019, PeerView

Suggest a CME Activity

Please provide below the URL and description of an activity you would like to add to OpenCME. You are welcome to add activities as often as you like. To prevent spam or other abuse, activities are reviewed by our editorial team before appearing on OpenCME.

OpenCME for Publishers

Please use the form below if you would like to offer your website visitors high-quality CME content by adding the OpenCME Widget to one or more of your pages.

Send Email to a Colleague

To share this activity with one or more colleagues, enter their e-mail addresses below. To include a personal message, simply overwrite the suggested text below.

(So your recipient knows it's from you.)
Enter multiple recipients separated by a space.
Optionally, replace/modify in the box above the message that will be sent to your colleague(s) with a link to download this app.