Activity Description and Educational Objectives
In this activity, experts in oncology and emergency medicine discuss principles of using immunotherapy to treat cancer, focusing specifically on the development of and recommendations for identifying, grading, and managing IMARs.
Upon completion of this activity, participants will be able to:
- Describe the basic principles of harnessing the human immune system in the treatment of cancer, including the mechanistic aspects of immune checkpoint inhibition and development of immune-mediated adverse reactions (IMARs)
- Characterize the spectrum of IMARs: organ systems potentially impacted, presenting symptoms, and timing of occurrence
- Discuss the general and organ-specific recommendations for evaluation, grading, and management of IMARs, including specific considerations for emergency care settings
- Implement recommended strategies for triage and management of IMARs in the emergency care setting
- Coordinate assessment and transition of care of patients experiencing IMARs with oncologists and medical subspecialists
Target Audience
This activity has been designed to meet the educational needs of emergency medicine physicians, advanced practice clinicians, nurses, pharmacists, and other healthcare professionals involved in the care of patients experiencing oncologic emergencies in the emergency department setting.
Requirements for Successful Completion
In order to receive credit, participants must view the activity and complete the post-test and evaluation form. A score of 70% or higher is needed to obtain CME/MOC/CNE/CPE credit. There are no pre-requisites and there is no fee to participate in this activity or to receive CME/MOC/CNE/CPE credit. Statements of Credit are awarded upon successful completion of the post-test and evaluation form.
Media: Enduring Material
Release and Expiration Dates: February 22, 2019 - February 21, 2020
Time to Complete: 60 minutes
Faculty and Disclosure / Conflict of Interest Policy
Before the activity, all faculty and anyone who is in a position to have control over the content of this activity and their spouse/life partner will disclose the existence of any financial interest and/or relationship(s) they might have with any commercial interest producing healthcare goods/services to be discussed during their presentation(s): honoraria, expenses, grants, consulting roles, speakers bureau membership, stock ownership, or other special relationships. Presenters will inform participants of any off-label discussions. All identified conflicts of interest are thoroughly vetted by Medical Learning Institute, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.
The associates of Medical Learning Institute, Inc., the accredited provider for this activity, and PVI, PeerView Institute for Medical Education do not have any financial relationships or relationships to products or devices with any commercial interest related to the content of this CME/MOC/CNE/CPE activity during the past 12 months.
Course Director
Evan J. Lipson, MD
Assistant Professor, Medical Oncology
Melanoma and Cancer Immunology Programs
Johns Hopkins University School of Medicine
The Sidney Kimmel Comprehensive Cancer Center
Baltimore, Maryland
Evan J. Lipson, MD, has a financial interest/relationship or affiliation in the form of:
Grant/Research Support from Bristol-Myers Squibb and Merck & Co., Inc.
Evan J. Lipson, MD, does not intend to discuss any non-FDA-approved or investigational use of any products/devices.
Faculty
Andrew Stolbach, MD, MPH
Medical Toxicologist
Emergency Physician
Associate Professor
Johns Hopkins University Department of Emergency Medicine
Baltimore, Maryland
Andrew Stolbach, MD, MPH, has a financial interest/relationship or affiliation in the form of:
Shareholder in Catalyst Biosciences and Portola Pharmaceuticals, Inc.
Andrew Stolbach, MD, MPH, does not intend to discuss any non-FDA-approved or investigational use of any products/devices.
Trish Brothers, BSN, RN, OCN®
Senior Research Nurse
Melanoma/Immunology
Johns Hopkins University School of Medicine
Baltimore, Maryland
Trish Brothers, BSN, RN, OCN®, has a financial interest/relationship or affiliation in the form of:
Grant/Research Support from Bristol-Myers Squibb.
Trish Brothers, BSN, RN, OCN®, does not intend to discuss any non-FDA-approved or investigational use of any products/devices.
Content Reviewers
Siyang Leng, MD, has no financial interests/relationships or affiliations in relation to this activity.
Tracy L. Greene, MSN, RN, FNP-C, Lead Nurse Planner, has no financial interests/relationships or affiliations in relation to this activity.
Janice Trainor-Tellier, MSN, RN, has no financial interests/relationships or affiliations in relation to this activity.
Teresa Haile, RPh, MBA, Lead Pharmacy Planner, has no financial interests/relationships or affiliations in relation to this activity.
Nancy Nesser, JD, PharmD, has no financial interests/relationships or affiliations in relation to this activity.
Medical Director
Kadrin Wilfong, MD
PVI, PeerView Institute for Medical Education
Kadrin Wilfong, MD, has no financial interests/relationships or affiliations in relation to this activity.
Disclaimer
The information provided at this CME/MOC/CNE/CPE activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a healthcare provider relative to diagnostic and treatment options of a specific patient’s medical condition. Recommendations for the use of particular therapeutic agents are based on the best available scientific evidence and current clinical guidelines. No bias towards or promotion for any agent discussed in this program should be inferred.
Providership, Credit, and Support
Physicians
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Medical Learning Institute, Inc. and PVI, PeerView Institute for Medical Education. The Medical Learning Institute, Inc. is accredited by the ACCME to provide continuing medical education for physicians.
The Medical Learning Institute, Inc. designates this enduring material for a maximum of 1.0
AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
MOC Statement

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.
Participation information will be shared with ABIM through the ACCME’s Program and Activity Reporting System (PARS). Blinded individual or aggregated participant data may be shared with the funder of the activity.
Nurses
Medical Learning Institute, Inc. is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.
Successful completion of this continuing nursing education activity will be awarded 1.0 contact hour(s).
Pharmacists

The Medical Learning Institute, Inc. is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. Completion of this application-based activity provides for 1.0 contact hour (0.10 CEU) of continuing pharmacy education credit. The Universal Activity Number for this activity is 0468-9999-18-015-H01-P.
Providership

This CME/MOC/CNE/CPE activity is jointly provided by Medical Learning Institute, Inc. and PVI, PeerView Institute for Medical Education.
Support
This activity is supported by an independent educational grant from AstraZeneca.
Disclosure of Unlabeled Use
The faculty of this educational activity may include discussions of products or devices that are not currently labeled for use by the FDA. Faculty members have been advised to disclose to the audience any reference to an unlabeled or investigational use.
No endorsement of unapproved products or uses is made or implied by coverage of these products or uses in our reports. No responsibility is taken for errors or omissions in reports. For approved prescribing information, please consult the manufacturer’s product labeling.
The materials presented here are used with the permission of the authors and/or other sources. These materials do not necessarily reflect the views of PeerView or any of its partners, providers, and/or supporters.
About This CME/MOC/CNE/CPE Activity
PVI, PeerView Institute for Medical Education, and Medical Learning Institute, Inc. are responsible for the selection of this activity’s topics, the preparation of editorial content, and the distribution of this activity. Our activities may contain references to unapproved products or uses of these products in certain jurisdictions. The preparation of PeerView activities is supported by educational grants subject to written agreements that clearly stipulate and enforce the editorial independence of PVI and Medical Learning Institute, Inc.
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