Course Director

Edward Garon, MD, MS
Edward Garon, MD, MS

David Geffen School of Medicine at UCLA
Los Angeles, California


John Heymach
John Heymach, MD, PhD

MD Anderson Cancer Center
Houston, Texas

Accredited by

Medical Learning Institute, Inc.

Activity Description

In this activity, experts in thoracic oncology discuss the latest options for treatment of EGFR-mutated advanced NSCLC, including the rationale for and evidence supporting dual targeting of VEGF and EGFR pathways as well as the role of the first FDA approved combination of VEGF and EGFR inhibitors for newly diagnosed patients. Additionally, the experts explore the nuances and practicalities of individualized treatment selection and sequencing throughout the continuum of advanced disease to maximally extend the benefits patients with EGFR-mutated NSCLC can derive from targeted therapies.

Target Audience

This activity has been designed to meet the educational needs of oncologists, oncology nurses, advanced practice clinicians, and other healthcare professionals involved in the care of patients with EGFR mutation–positive NSCLC.

Educational Objectives

Upon completion of this activity, participants will be able to:
  • Discuss the current understanding of the underlying biology of EGFR mutations in NSCLC, including exon 19 and 21 mutations, and mechanisms of acquired resistance, such as T790M, and their implications for treatment selection in first-line and later lines of therapy in advanced EGFR mutation–positive NSCLC
  • Assess the mechanistic rationale for targeting the VEGFR and EGFR pathways through combination therapy
  • Cite updated evidence on validated treatment options and emerging evidence on the use of novel regimens in the management of EGFR-mutated NSCLC, including newer antiangiogenic and TKI combinations or agents
  • Implement evidence-based, individualized, precision treatment plans for patients with advanced EGFR-mutant NSCLC, including for those patients who acquire resistance on prior lines of treatment

Providership, Credit, and Support

This CME/MOC/CNE activity is jointly provided by Medical Learning Institute, Inc. and PVI, PeerView Institute for Medical Education.

This activity is supported by an educational grant from Lilly. For further information concerning Lilly grant funding visit

Physician Continuing Medical Education

ACCMEThis activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Medical Learning Institute, Inc. and PVI, PeerView Institute for Medical Education. The Medical Learning Institute, Inc. is accredited by the ACCME to provide continuing medical education for physicians.

The Medical Learning Institute, Inc. designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

MOC Statement

MOCSuccessful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Participation information will be shared with ABIM through the ACCME’s Program and Activity Reporting System (PARS). Blinded individual or aggregated participant data may be shared with the funder of the activity.

Continuing Nursing Education

ANCCMedical Learning Institute, Inc. is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.
Successful completion of this continuing nursing education activity will be awarded 1.0 contact hour(s).

Faculty Disclosures

Edward Garon, MD, MS
Professor of Medicine
David Geffen School of Medicine at UCLA
Director of Thoracic Oncology
Los Angeles, California

Edward Garon, MD, MS, has a financial interest/relationship or affiliation in the form of:
Consultant and/or Advisor for Dracen Pharmaceuticals; EMD Serono, Inc.; GlaxoSmithKline; and Novartis Pharmaceuticals Corporation.
Grant/Research Support from AstraZeneca; Bristol Myers Squibb; Dynavax Technologies; Eli Lilly and Company; EMD Serono; Genentech, Inc.; Iovance Biotherapeutics, Inc.; Merck & Co., Inc.; Mirati Therapeutics, Inc.; Neon; Novartis Pharmaceuticals Corporation.

John Heymach, MD, PhD
Professor and Chair, Dept. of Thoracic/Head and Neck Medical Oncology
MD Anderson Cancer Center
Houston, Texas

John Heymach, MD, PhD, has a financial interest/relationship or affiliation in the form of:
Consultant and/or Advisor for AstraZeneca, BioTree, Boehringer Ingelheim GmbH; Catalyst Pharmaceuticals, Inc.; Eli Lilly and Company; EMD Serono, Inc.; Genentech, Inc.; GlaxoSmithKline; Guardant Health; Hengrui Therapeutics, Inc.; Novartis Pharmaceuticals Corporation; sanofi-aventis U.S. LLC ; Spectrum Pharmaceuticals, Inc.; and Synta Pharmaceuticals.
Grant/Research Support from AstraZeneca; Bayer; GlaxoSmithKline; and Spectrum Pharmaceuticals, Inc.
Other Financial or Material Support Royalties and Licensing Fees with Spectrum Pharmaceuticals, Inc.

Planning Committee Disclosures

Tracy L. Greene, MSN, RN, FNP-C, Nurse Planner, MLI, has nothing to disclose.

The planners from Medical Learning Institute, Inc., the accredited provider, and PeerView Institute for Medical Education, the joint provider, do not have any financial relationships with an ACCME-defined commercial interest related to the content of this accredited activity during the past 12 months unless listed below.

Content/Peer Reviewer Disclosures

The following Content/Peer Reviewers have nothing to disclose:

Jim Zhai, MD, FCAP
Pamela Ash, RN, MSN, CBCN

Disclosure of Unlabeled Use

This educational activity may contain discussions of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities.

Method of Participation

There are no fees for participating in or receiving credit for this accredited activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

A statement of credit will be issued only upon receipt of a completed activity evaluation form and will be emailed to you upon completion. You will receive your certificate from If you have questions regarding the receipt of your emailed certificate, please contact via email at

In order to receive credit, participants must view the activity and complete the post-test and evaluation form. A score of 70% or higher is needed to obtain MOC/CNE credit. There are no prerequisites and there is no fee to participate in this activity or to receive MOC/CNE credit. Statements of Credit are awarded upon successful completion of the post-test and evaluation form.

About This CME/MOC/CNE Activity

PVI, PeerView Institute for Medical Education, and Medical Learning Institute, Inc. are responsible for the selection of this activity’s topics, the preparation of editorial content, and the distribution of this activity. Our activities may contain references to unapproved products or uses of these products in certain jurisdictions. The preparation of PeerView activities is supported by educational grants subject to written agreements that clearly stipulate and enforce the editorial independence of PVI and Medical Learning Institute, Inc.

The materials presented here are used with the permission of the authors and/or other sources. These materials do not necessarily reflect the views of PeerView or any of its partners, providers, and/or supporters.

Copyright © 2000-2020, PeerView

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