Course Directors

Kathryn Beal, MD
Kathryn Beal, MD

Memorial Sloan Kettering Cancer Center
New York, New York

Sandip Patel, MD
Sandip Patel, MD

UC San Diego Health
San Diego Center for Precision Immunotherapy
UC San Diego Moores Cancer Center
La Jolla, California


Manmeet Ahluwalia
Manmeet Ahluwalia, MD, FACP

Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic
Cleveland Clinic Lerner College of Medicine of the Case Western Reserve University
Cleveland, Ohio

Media: Enduring Material
Accredited Activity Release Date: November 4, 2019
Accredited Activity Expiration Date: November 3, 2020
Time to Complete Activity: 90 minutes

Activity Description

Central nervous system (CNS) metastases occur commonly in patients with lung cancer, and those patients with epidermal growth factor receptor (EGFR)-mutant non–small cell lung cancer (NSCLC) are particularly prone to their development. Treatment of brain metastases is challenging, and there are varied perspectives among different specialists about the best approach—if, when, and how to use local therapies, systemic therapies, or different treatment modalities in combination or sequence, etc. Clinical trials are underway to try to answer some of these critical questions about which treatment strategies yield the best results for these patients.

This PeerView Live MasterClass and Practicum on-demand educational activity features a panel of multidisciplinary experts in EGFR-mutant lung cancer and CNS metastases who discuss the evolving evidence, clinical challenges, and practicalities of patient care. Real cases are debated from multiple perspectives, with an emphasis on information and guidance relevant for radiation oncologists.

Target Audience

This activity has been designed to meet the educational needs of radiation oncologists, medical oncologists, surgeons, neuro-oncologists, and other healthcare professionals involved in the care of patients with NSCLC and CNS metastases.

Educational Objectives

Upon completion of this activity, participants should be better able to:
  • Describe molecular pathways that drive malignancy in lung cancer and the oncogenic activation of tyrosine kinases, such as mutations in EGFR, and the epidemiology and presentation of CNS metastases in EGFR-mutant lung cancer
  • Discuss the mechanisms of action, characteristics, and safety/efficacy profiles of the various EGFR TKIs available for the treatment of EGFR-mutant NSCLC throughout the continuum of advanced disease, including in patients with CNS metastases
  • Summarize the efficacy and safety data of available and emerging treatment strategies used in the management of brain or leptomeningeal metastases in patients with EGFR-mutant NSCLC, including the use of local therapies such as radiation, systemic therapies such as EGFR TKIs, and sequential/combination treatment approaches
  • Implement individualized treatment plans for patients with EGFR-mutant lung cancer with CNS metastases, including in the context of clinical practice or clinical trials, based on the latest evidence, recommendations, and effective multidisciplinary collaboration and coordination of care

Providership, Credit, and Support

This CME/MOC activity is jointly provided by Medical Learning Institute, Inc. and PVI, PeerView Institute for Medical Education.

This activity is supported by an independent educational grant from AstraZeneca.

Physician Continuing Medical Education

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Medical Learning Institute, Inc. and PVI, PeerView Institute for Medical Education. The Medical Learning Institute, Inc. is accredited by the ACCME to provide continuing medical education for physicians.

The Medical Learning Institute, Inc. designates this enduring material for a maximum of 1.5 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

MOC Statement

ABIM MOCSuccessful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.5 MOC points and patient safety MOC credit in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Participation information will be shared with ABIM through the ACCME’s Program and Activity Reporting System (PARS). Blinded individual or aggregated participant data may be shared with the funder of the activity.

Faculty Disclosures

Kathryn Beal, MD
Radiation Oncologist
Director of Brain Tumor Service at Radiation Oncology
Memorial Sloan Kettering Cancer Center
New York, New York

Kathryn Beal, MD, has a financial interest/relationship or affiliation in the form of:
Stock Shareholder in Magnolia Medical Technologies.

Sandip Patel, MD
Associate Professor, Department of Medicine
UC San Diego Health
Co-Leader, Experimental Therapeutics
Deputy Director, San Diego Center for Precision Immunotherapy
Assistant Director, Clinical Trials Office
UC San Diego Moores Cancer Center
La Jolla, California

Sandip Patel, MD, has a financial interest/relationship or affiliation in the form of:
Consultant and/or Advisor for AstraZeneca; Bristol-Myers Squibb; Eli Lilly and Company; Illumina, Inc.; Nektar Therapeutics; and Tempus.

Manmeet Ahluwalia, MD, FACP
Miller Family Endowed Chair in NeuroOncology
Associate Director and Head of Operations
Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic
Professor, Cleveland Clinic Lerner College of Medicine of the Case Western Reserve University
Cleveland, Ohio

Manmeet Ahluwalia, MD, FACP, has a financial interest/relationship or affiliation in the form of:
Consultant and/or Advisor for AbbVie Inc.; AstraZeneca; Bayer Corporation; Elsevier; Flatiron; Forma Therapeutics; Karyopharm; Varian Medical Systems, Inc.; Tocagen; Varian Medical Systems, Inc.; and VBI Vaccines Inc.
Grant/Research Support from AbbVie Inc.; AstraZeneca; Bayer Corporation; Bristol-Myers Squibb; Incyte Corporation; Novocure; Merck & Co., Inc.; and Pharmacyclics LLC.
Stock Shareholder in Doctible and MimiVax.
Other financial interest/relationship in Wiley in the from of royalties as the book editor.

Planning Committee Disclosures

The planners from Medical Learning Institute, Inc., the accredited provider, and PeerView Institute for Medical Education, the joint provider, do not have any financial relationships with an ACCME-defined commercial interest related to the content of this accredited activity during the past 12 months unless listed below.

Content/Peer Reviewer Disclosures

The following Content/Peer Reviewers have nothing to disclose:

Shaina Rozell, MD, MPH
Amita B. Patel, MSN, RN, AOCNP, NP-C

Disclosure of Unlabeled Use

This educational activity may contain discussions of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities.

Method of Participation

There are no fees for participating in or receiving credit for this accredited activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

A statement of credit will be issued only upon receipt of a completed activity evaluation form and will be emailed to you upon completion. You will receive your certificate from If you have questions regarding the receipt of your emailed certificate, please contact via email at

In order to receive credit, participants must view the activity and complete the post-test and evaluation form. A score of 70% or higher is needed to obtain MOC credit. There are no pre-requisites and there is no fee to participate in this activity or to receive MOC credit. Statements of Credit are awarded upon successful completion of the post-test and evaluation form.

About This CME/MOC Activity

PVI, PeerView Institute for Medical Education, and Medical Learning Institute, Inc. are responsible for the selection of this activity’s topics, the preparation of editorial content, and the distribution of this activity. Our activities may contain references to unapproved products or uses of these products in certain jurisdictions. The preparation of PeerView activities is supported by educational grants subject to written agreements that clearly stipulate and enforce the editorial independence of PVI and Medical Learning Institute, Inc.

The materials presented here are used with the permission of the authors and/or other sources. These materials do not necessarily reflect the views of PeerView or any of its partners, providers, and/or supporters.

Copyright © 2000-2019, PeerView

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