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Faculty

Michelle Kelsey, MD

Vishal Rao, MD

Amanda Coniglio, MD

Accredited by

American College of Cardiology

Course Description

Using serial analysis of myocardial gene expression employing endomyocardial biopsy starting material in a dilated cardiomyopathy cohort, we show that mRNA expression of the severe acute respiratory syndromecoronavirus- 2 (SARS-CoV-2) cardiac myocyte receptor ACE2 is up-regulated with remodeling and with reverse remodeling down-regulates into the normal range. The proteases responsible for virus-cell membrane fusion were expressed but not regulated with remodeling. In addition, a new candidate for SARS-CoV-2 cell binding and entry was identified, the integrin encoded by ITGA5. Up-regulation in ACE2 in remodeled left ventricles may explain worse outcomes in patients with coronavirus disease 2019 who have underlying myocardial disorders, and counteracting ACE2 up-regulation is a possible therapeutic approach to minimizing cardiac damage.

Activity Details

Credit Types:CME
Credit Amount:1.00 Credits
Release Date:2020-Sep-28
Expiration Date:2021-Sep-27
Registration Required:Yes
Cost:Free

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