Michelle Kelsey, MD

Vishal Rao, MD

Amanda Coniglio, MD

Accredited by

American College of Cardiology

Course Description

Using serial analysis of myocardial gene expression employing endomyocardial biopsy starting material in a dilated cardiomyopathy cohort, we show that mRNA expression of the severe acute respiratory syndromecoronavirus- 2 (SARS-CoV-2) cardiac myocyte receptor ACE2 is up-regulated with remodeling and with reverse remodeling down-regulates into the normal range. The proteases responsible for virus-cell membrane fusion were expressed but not regulated with remodeling. In addition, a new candidate for SARS-CoV-2 cell binding and entry was identified, the integrin encoded by ITGA5. Up-regulation in ACE2 in remodeled left ventricles may explain worse outcomes in patients with coronavirus disease 2019 who have underlying myocardial disorders, and counteracting ACE2 up-regulation is a possible therapeutic approach to minimizing cardiac damage.

Activity Details

Credit Types:CME
Credit Amount:1.00 Credits
Release Date:2020-Sep-28
Expiration Date:2021-Sep-27
Registration Required:Yes

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