Course Director

Sorayah Bourenane, MSN, RN, CNL
Sorayah Bourenane, MSN, RN, CNL

The University of Texas MD Anderson Cancer Center
Houston, Texas


Marianne Davies
Marianne Davies, DNP, ACNP, AOCNP

Yale School of Nursing
Yale Comprehensive Cancer Center & Smilow Cancer Center
New Haven, Connecticut

Accredited by

Medical Learning Institute, Inc.

Activity Description

Treatment of cancer has been transformed by the new immune checkpoint inhibitor class of agents that have shown remarkable benefit in many different types of tumors, but they can also cause unusual immune-related adverse effects (irAEs) that can affect any organ system. Expanding use of these immunotherapies in oncology means that emergency medicine professionals can expect to encounter an increasing number of patients experiencing various irAEs in emergency departments. Timely recognition, accurate diagnosis, and effective management of irAEs can ensure that patients derive maximum benefit from these therapies, and emergency nurses have an important role to play in evaluating and triaging these patients.

This CNE educational on-demand activity combines lessons on everything emergency nurses need to know about cancer immunotherapies and irAEs with case discussions and practical guidance for keeping patients with cancer safe in the era of immuno-oncology.

Target Audience

This activity has been designed to meet the educational needs of emergency nurses and other healthcare professionals involved in the triage, diagnosis, and management of immune-related adverse effects associated with cancer immunotherapies in the ED.

Educational Objectives

Upon completion of this activity, participants will be able to:
  • Describe the basic principles of harnessing the human immune system in the treatment of cancer, including the mechanistic aspects of immune checkpoint inhibition and development of immune-related adverse effects (irAEs)
  • Characterize the presenting symptoms of the spectrum of irAEs associated with immune checkpoint inhibitors and combinations, including those most likely to be encountered by emergency nurses and other professionals in the emergency department (ED)
  • Outline the general and organ/site-specific recommendations for the recognition, evaluation, diagnosis/differential diagnosis, and management of irAEs in the ED
  • Implement recommended strategies for triage, evaluation, diagnosis, and management of relevant irAEs in EM settings in collaboration with oncology specialists

Providership, Credit, and Support

This CNE activity is jointly provided by Medical Learning Institute, Inc. and PVI, PeerView Institute for Medical Education.

This activity is supported through educational grants from Bristol-Myers Squibb and Merck & Co., Inc.

Continuing Nursing Education

Medical Learning Institute, Inc. is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center's Commission on Accreditation.
Successful completion of this continuing nursing education activity will be awarded 1.0 contact hour(s).

Faculty Disclosures

Sorayah Bourenane, MSN, RN, CNL
Clinical Nurse Leader
Emergency Center (EC) and Clinical Decision Unit (CDU)
The University of Texas MD Anderson Cancer Center
Houston, Texas

Sorayah Bourenane, MSN, RN, CNL, has no financial interest/relationship or affiliations in relation to this activity.

Marianne Davies, DNP, ACNP, AOCNP
Associate Professor
Yale School of Nursing
Oncology Nurse Practitioner
Yale Comprehensive Cancer Center & Smilow Cancer Center
New Haven, Connecticut

Marianne Davies, DNP, ACNP, AOCNP, has a financial interest/relationship or affiliation in the form of:
Speakers Bureau participant with AstraZeneca; Bristol-Myers Squibb; Genentech, Inc.; and Merck & Co., Inc.

Planning Committee Disclosures

Tracy L. Greene, MSN, RN, FNP-C, Lead Nurse Planner, MLI, has nothing to disclose.

The planners from Medical Learning Institute, Inc., the accredited provider, and PeerView Institute for Medical Education, the joint provider, do not have any financial relationships with an ACCME-defined commercial interest related to the content of this accredited activity during the past 12 months unless listed below.

Content/Peer Reviewer Disclosures

The following Content/Peer Reviewer has nothing to disclose:

Amita B. Patel, MSN, RN, AOCNP, NP-C

Disclosure of Unlabeled Use

This educational activity may contain discussions of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities.

Method of Participation

There are no fees for participating in or receiving credit for this accredited activity. For information on applicability and acceptance of continuing education credit for this activity, please consult your professional licensing board.

A statement of credit will be issued only upon receipt of a completed activity evaluation form and will be emailed to you upon completion. You will receive your certificate from If you have questions regarding the receipt of your emailed certificate, please contact via email at

In order to receive credit, participants must view the activity and complete the post-test and evaluation form. A score of 70% or higher is needed to obtain CNE credit. There are no pre-requisites and there is no fee to participate in this activity or to receive CNE credit. Statements of Credit are awarded upon successful completion of the post-test and evaluation form.

About This CNE Activity

PVI, PeerView Institute for Medical Education, and Medical Learning Institute, Inc. are responsible for the selection of this activity’s topics, the preparation of editorial content, and the distribution of this activity. Our activities may contain references to unapproved products or uses of these products in certain jurisdictions. The preparation of PeerView activities is supported by educational grants subject to written agreements that clearly stipulate and enforce the editorial independence of PVI and Medical Learning Institute, Inc.

The materials presented here are used with the permission of the authors and/or other sources. These materials do not necessarily reflect the views of PeerView or any of its partners, providers, and/or supporters.

Copyright © 2000-2019, PeerView

Suggest a CME Activity

Please provide below the URL and description of an activity you would like to add to OpenCME. You are welcome to add activities as often as you like. To prevent spam or other abuse, activities are reviewed by our editorial team before appearing on OpenCME.

OpenCME for Publishers

Please use the form below if you would like to offer your website visitors high-quality CME content by adding the OpenCME Widget to one or more of your pages.

Send Email to a Colleague

To share this activity with one or more colleagues, enter their e-mail addresses below. To include a personal message, simply overwrite the suggested text below.

(So your recipient knows it's from you.)
Enter multiple recipients separated by a space.
Optionally, replace/modify in the box above the message that will be sent to your colleague(s) with a link to download this app.