Course Director

Leonard Calabrese
Leonard Calabrese, DO

Department of Rheumatic & Immunologic Diseases
Cleveland Clinic
Cleveland, OH


R. John Looney, MD

Professor of Medicine
Department of Allergy, Immunology, & Rheumatology
University of Rochester Medical Center
Rochester, NY

Accredited by

Cleveland Clinic Center for Continuing Education

View Activity Materials

Course Description

Learning Objectives
1. List the characteristic effector cytokines produced by each of the 5 major CD4 T cell subsets.
2. Describe the infections resulting from defects in TH1 or TH17, or Tfh cells.
3. Describe the effect of TH2 cells overactivity on infections.
4. Describe the role of TH17 cells in the induction of osteoclasts and the bone erosions associated with inflammatory arthritis. And, describe the effects of TH1 and TH2 cells on the induction of osteoclasts by TH17 cells.
5. Describe non-classical TH1 cells (also know as ex-TH17 cells) and how the multiple cytokine produced by these cells complicate treatment.
6. Describe tissue resident T cells and how they are involved in the Koebner phenomenon.

Activity Details

Credit Types:CME
Credit Amount:0.50 Credits
Release Date:2020-Apr-08
Expiration Date:2022-Apr-08
Estimated Time for Completion:30 minutes
Registration Required:No

Suggest a CME Activity

Please provide below the URL and description of an activity you would like to add to OpenCME. You are welcome to add activities as often as you like. To prevent spam or other abuse, activities are reviewed by our editorial team before appearing on OpenCME.

OpenCME for Publishers

Please use the form below if you would like to offer your website visitors high-quality CME content by adding the OpenCME Widget to one or more of your pages.

Send Email to a Colleague

To share this activity with one or more colleagues, enter their e-mail addresses below. To include a personal message, simply overwrite the suggested text below.

(So your recipient knows it's from you.)
Enter multiple recipients separated by a space.
Optionally, replace/modify in the box above the message that will be sent to your colleague(s) with a link to download this app.