Michelle Kelsey, MD

Vishal Rao, MD

Amanda Coniglio, MD

Accredited by

American College of Cardiology

Course Description

The feasibility of rapid genetic testing in patients undergoing percutaneous coronary intervention (PCI) and the comparison of the pharmacodynamic effects of prasugrel versus ticagrelor among carriers of cytochrome P450 2C19 loss-of-function alleles treated with PCI has been poorly explored. Rapid genetic testing using the Spartan assay was shown to be feasible and provides results in a timely fashion in a real-world setting of patients undergoing coronary angiography (n = 781). Among patients (n = 223, 28.5%), carriers of at least 1 loss-of-function allele treated with PCI (n = 65), prasugrel, and ticagrelor achieve similar levels of platelet inhibition.

Learner Objectives

- Compare the mechanisms of action and pharmacokinetics of P2Y12 receptor antagonists.
- Identify the genetic alleles relevant to clopidogrel metabolism.
- Discuss the various indications and cutoffs for fractional flow reserve and instantaneous wave-free ratio testing to guide coronary intervention.

Activity Details

Credit Types:CME
Credit Amount:1.00 Credits
Release Date:2020-May-25
Expiration Date:2021-May-24
Registration Required:Yes

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